K1764
Kazusamycin A
from Streptomyces sp., ≥95% (HPLC), aqueous methanol solution
SMILES string
CCC(\C=C\C1OC(=O)C=CC1C)=C/C(C)C\C=C\C(C)=C\C(CO)C(=O)C(C)C(O)C(C)C\C(C)=C\C(O)=O
biological source
Streptomyces sp.
assay
≥95% (HPLC)
form
aqueous methanol solution
solubility
methanol: water: soluble 7:3, DMSO: soluble, H2O: insoluble, chloroform: soluble, ethanol: soluble, hexane: insoluble, methanol: soluble
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
Kazusamycin A, an unsaturated branched chain fatty acid with a terminal lactone ring, is a hydroxy analog of Leptomycin B. It has significant in vitro cytotoxic activity against various human and mouse tumor lines encompassing a wide range of tissue types. Kazusamycin A exhibits in vivo antitumor activity against experimental murine tumors. It inhibits nuclear export and Rev translocation, a regulatory gene product in the HIV genome, at nanomolar concentrations.
Physical form
70% methanol solution.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
存储类别
3 - Flammable liquids
wgk
WGK 1
flash_point_f
60.0 °F - closed cup
flash_point_c
15.56 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
The effect of kazusamycin on the growth of murine solid tumors and their spontaneous metastasis.
E Yoshida et al.
The Journal of antibiotics, 40(3), 391-393 (1987-03-01)
I Umezawa et al.
The Journal of antibiotics, 37(7), 706-711 (1984-07-01)
A new antibiotic kazusamycin, was isolated from the culture broth of Streptomyces sp. No. 81-484, which shows antitumor activity against experimental murine tumors. This antibiotic did not possess antibacterial activity against Gram-positive and Gram-negative bacteria, but showed strong cytotoxic activity
M Sawamura
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 83(5), 627-635 (1992-05-01)
Kazusamycin A (KZMA) is a new anticancer antibiotic, which has been proven to have strong anticancer effect and several characteristic features different from currently available anticancer antibiotics. However, there has as yet been no report which had concerned itself with
Wang, Y., et al.
Helvetica Chimica Acta, 80, 2157-2167 (1997)
Noriyoshi Arai et al.
Organic letters, 6(17), 2845-2848 (2004-08-28)
The first total synthesis of kazusamycin A, a potent antitumor compound from an actinomycete, has been achieved, and its absolute structure was determined. Paterson's stereoselective aldol reaction was successfully applied to construct the contiguous chiral centers by using an originally
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