K2638
激肽释放酶 来源于人类血浆
buffered aqueous solution, ≥5 units/mg protein
别名:
激肽原, 激肽原酶
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
Specific activity:
≥5 units/mg protein
form
buffered aqueous solution
specific activity
≥5 units/mg protein
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Quality Level
Gene Information
human ... KLK1(3816)
General description
Kallikrein肽酶属于15个高度保守的胰蛋白酶或胰凝乳蛋白酶家庭的成员。血浆激肽释放酶（PK）是一种来源于血浆前激肽释放酶的丝氨酸蛋白酶，也是一种在血液循环中含量较高的酶原。KLKB1基因位于人染色体4q35.2上。
Application
从人血浆中提取的激肽释放酶已用于：
- 培养人肝癌细胞系
- 研究其对来自脑膜炎奈瑟氏菌的奈瑟球菌肝素结合抗原（NHBA）的裂解作用
- 肽酶抑制分析
Biochem/physiol Actions
血浆激肽释放酶（PK）参与缓激肽的合成，可维持血液代谢物水平和高血压。它还参与凝血因子XII的激活，促进炎症和内源性凝血途径。PK控制心血管系统中的蛋白水解级联反应，如激肽酶激肽系统、肾素血管紧张素系统、纤维蛋白溶解系统和补体旁路等。它参与胰高血糖素样肽-1（GLP-1）和神经肽Y（NPY） 的裂解，这表明血浆激肽释放酶可能会影响代谢和糖尿病。
Physical form
溶于20 mM Tris-HCl (pH 7.8)和100 mM NaCl的溶液中。
Other Notes
一个酶活性单位是指在pH 8.7、25°C条件下，每分钟将1.0 μMNα-苯甲酰基-L-精氨酸乙酯（BAEE）水解为Nα-苯甲酰基-L-精氨酸和乙醇所需的酶量。
存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
高风险级别生物产品--人源产品
此项目有
Xueqing Xu et al.
Nucleic acids research, 37(22), 7381-7393 (2009-10-13)
A subtelomeric region, 4q35.2, is implicated in facioscapulohumeral muscular dystrophy (FSHD), a dominant disease thought to involve local pathogenic changes in chromatin. FSHD patients have too few copies of a tandem 3.3-kb repeat (D4Z4) at 4q35.2. No phenotype is associated
Ekaterina Zubareva et al.
Pharmaceuticals (Basel, Switzerland), 14(11) (2021-11-28)
The disfunction or deficiency of the C1 esterase inhibitor (C1INH) is associated with hereditary or acquired angioedema (HAE/AAE), a rare life-threatening condition characterized by swelling in the skin, respiratory and gastrointestinal tracts. The current treatment options may carry the risks
Elisa Pantano et al.
PloS one, 14(8), e0203234-e0203234 (2019-08-02)
Neisserial Heparin Binding Antigen (NHBA) is a surface-exposed lipoprotein of Neisseria meningitidis and a component of the Bexsero vaccine. NHBA is characterized by the presence of a highly conserved Arg-rich region involved in binding to heparin and heparan sulphate proteoglycans
Georgia Sotiropoulou et al.
The Journal of biological chemistry, 284(48), 32989-32994 (2009-10-13)
Kallikrein-related peptidases constitute a single family of 15 (chymo)trypsin-like proteases (KLK1-15) with pleiotropic physiological roles. Aberrant regulation of KLKs has been associated with diverse diseases such as hypertension, renal dysfunction, skin disorders, inflammation, neurodegeneration, and cancer. Recent studies suggested that
R Dellalibera-Joviliano et al.
Scandinavian journal of immunology, 72(2), 128-133 (2010-07-14)
Some components of the kinin system such as plasma kallikrein levels, the activities of tissue kallikrein (including saliva) and kininase II and the concentrations of kininogen fractions (low-molecular weight/LKg and high-molecular weight/HKg) were evaluated in the plasma of patients with
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