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Merck
CN

L0881

Sigma-Aldrich

花生的凝集素

lyophilized powder, Affinity-purified

别名:

PNA, 花生凝集素

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关于此项目

UNSPSC代码:
12352202
NACRES:
NA.32

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表单

lyophilized powder

质量水平

200

效能

<0.1 μg per mL agglutination activity

质量

Affinity-purified

杂质

salt, free

储存温度

−20°C

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相关类别

一般描述

从 Arachis hypogaea （花生）中提取的凝集素是分子量 110 kDa的同四聚体蛋白。

应用

从 Arachis hypogaea （花生）中提取的凝集素用于：
  • 检测 Thomson-Friedenreich 抗原
  • 作为PBS的成分，研究其对细胞活力的影响
  • 研究其阻断结合位点的能力

生化/生理作用

从Arachis hypogaea （花生）中提取的凝集素对 Thomson − Friedenreich 抗原的 β -D-Gal(1-3)-D-galNAc 残基具有特异性。 在许多鳞状细胞癌诊断和预后中，是最广泛使用的标志物。
花生凝集素不会凝集正常的人类红细胞，但会强烈凝集神经氨酸酶处理的红细胞。花生凝集素具有与人血清中的抗 T 抗体相似的有效抗 T 活性。凝集素可用于区分人淋巴细胞亚群。

分析说明

凝集活性以 μg/ml 表示，并根据 1 mg/mL 溶液在磷酸盐缓冲盐水 (pH 6.8) 中的系列稀释液测定。该活性是在 25°C 下孵育 1 h 后凝集 2% 神经氨酸酶处理的人 O 型红细胞悬液的最低浓度。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

动植物源性产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000404001
0000404000
0000404000
0000404001
0000359864

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  1. How does the storage temperature relate to shipping conditions?

    The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment. See Shipping and Storage for more information.

  2. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  3. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  4. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  5. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  6. Is the peanut lectin (Lectin from Arachis hypogaea) a glycoprotein?  If so, what is the carbohydrate content?

    Peanut lectin is not a glycoprotein. Although peanut lectin binds specifically to a particular carbohydrate (beta-gal(1-->3)galNac) in other molecules, the lectin itself does not contain any carbohydrate.  Please see page 231 of the following paper: R. Banerjee, et al., "Crystal structure of peanut lectin, a protein with an unusual quaternary structure".  Proc. Nat. Acad. Sci., USA, 91, 227-231 (1994).

  7. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Adhesion of plant roots to poly-L-lysine coated polypropylene substrates
Towler MJ and Weathers PJ
Journal of Biotechnology, 101(2), 147-155 (2003)
Expression of peanut agglutinin-binding mucin-type glycoprotein in human esophageal squamous cell carcinoma as a marker
Kannan S, et al.
Molecular Cancer, 2(1), 38-38 (2003)
Peter Gassmann et al.
BMC cancer, 10, 177-177 (2010-05-04)
Metastasis formation is the leading cause of death among colon cancer patients. We established a new in-situ model of in vivo microscopy of the lung to analyse initiating events of metastatic tumor cell adhesion within this typical metastatic target of
Lectin binding and effects in culture on human cancer and non-cancer cell lines: examination of issues of interest in drug design strategies
Petrossian K, et al.
Acta Histochemica, 109(6), 491-500 (2007)
In vitro and in vivo antitumor effects of Peanut agglutinin through induction of apoptotic and autophagic cell death
Mukhopadhyay S, et al.
Food And Chemical Toxicology, 64, 369-377 (2014)
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