Anti-Leukemia Inhibitory Factor antibody produced in goat

Leukemia inhibitory factor (LIF) is a pleotropic glycoprotein that belongs to the IL6 family of cytokines. It is secreted by many cell types such as, fibroblasts, macrophages, T cells, monocytes, liver cells, osteoblasts and cells of endometrium. LIF interacts with a heterodimeric receptor composed of two subunits, gp130 and gp190. A variety of signal transduction pathways are triggered in response to LIF including ERK/MAPK, JAK1, PI3K, STAT3, Jun-cFos and NF-κB. The various functions of LIF include proliferation of adult human T cells, maintenance of pluripotency of embryonic stem cells and inhibition of leukemic ell differentiation. Reports also indicate the important role of LIF in lactation, tissue regeneration after brain and spinal cord injury, muscle regeneration and motor neuron functions.
Anti-Leukemia Inhibitory Factor recognizes human leukemia inhibitory factor. It shows less than 30% cross-reactivity with recombinant mouse LIF.

purified, E. coli-derived recombinant human leukemia inhibitory factor.

Anti-Leukemia Inhibitory Factor may be used for immunoblotting at a working a concentration of 0.1-0.2 μg/ml. For immunohistochemistry, a concentration of 25 μg/ml may be used. The antibody is also suitable for neutralization reactions.

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.