L1169
Anti-Leukemia Inhibitory Factor antibody produced in goat
affinity isolated antibody, lyophilized powder
别名:
CDF, D factor, DIA, Emfilermin, LIF, differentiation inhibitory activity
一般描述
Leukemia inhibitory factor (LIF) is a pleotropic glycoprotein that belongs to the IL6 family of cytokines. It is secreted by many cell types such as, fibroblasts, macrophages, T cells, monocytes, liver cells, osteoblasts and cells of endometrium. LIF interacts with a heterodimeric receptor composed of two subunits, gp130 and gp190. A variety of signal transduction pathways are triggered in response to LIF including ERK/MAPK, JAK1, PI3K, STAT3, Jun-cFos and NF-κB. The various functions of LIF include proliferation of adult human T cells, maintenance of pluripotency of embryonic stem cells and inhibition of leukemic ell differentiation. Reports also indicate the important role of LIF in lactation, tissue regeneration after brain and spinal cord injury, muscle regeneration and motor neuron functions.
Anti-Leukemia Inhibitory Factor recognizes human leukemia inhibitory factor. It shows less than 30% cross-reactivity with recombinant mouse LIF.
Anti-Leukemia Inhibitory Factor recognizes human leukemia inhibitory factor. It shows less than 30% cross-reactivity with recombinant mouse LIF.
免疫原
purified, E. coli-derived recombinant human leukemia inhibitory factor.
应用
Anti-Leukemia Inhibitory Factor may be used for immunoblotting at a working a concentration of 0.1-0.2 μg/ml. For immunohistochemistry, a concentration of 25 μg/ml may be used. The antibody is also suitable for neutralization reactions.
外形
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Ekaterini A Kritikou et al.
Development (Cambridge, England), 130(15), 3459-3468 (2003-06-18)
STAT3 is the key mediator of apoptosis in mammary gland. We demonstrate here that LIF is the physiological activator of STAT3, because in involuting mammary glands of Lif(-/-) mice, pSTAT3 is absent and the STAT3 target, C/EBPdelta, is not upregulated.
Sylvian Bauer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(46), 12089-12099 (2006-11-17)
Although neural stem cells (NSCs) persist in various areas of the adult brain, their contribution to brain repair after injury is very limited. Treatment with exogenous growth factors can mitigate this limitation, suggesting that the brain environment is normally deficient
S M Metcalfe
Genes and immunity, 12(3), 157-168 (2011-03-04)
At the heart of lineage commitment within the adaptive immune response is the intrinsic genetic plasticity of the naive peripheral T lymphocyte (T cell). Primary activation by presentation of cognate antigen is coupled to rapid T-cell cycling and progressive epigenetic
D J Hilton
Trends in biochemical sciences, 17(2), 72-76 (1992-02-01)
Leukaemia inhibitory factor (LIF) is one of a growing number of cytokines that cannot be readily categorized according to its functions. Rather, these pleiotropic hormones have diverse and often overlapping effects on a multitude of cell types: for example, LIF
L C Hunt et al.
Experimental cell research, 316(6), 1002-1009 (2009-12-08)
Leukemia inhibitory factor (LIF) is an important regulator of skeletal muscle regeneration and has been suggested to be mitogenic for myogenic cells because it has been shown to increase the quantity of myoblast cells grown in culture over extended periods
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持