L1663
Lidocaine N-ethyl chloride
sodium channel blocker
别名:
N-(2,6-Dimethylphenylcarbamoylmethyl) triethylammonium chloride
Product Name
Lidocaine N-ethyl chloride,
储存条件
protect from light
质量水平
溶解性
H2O: soluble
储存温度
room temp
SMILES字符串
[Cl-].CC[N+](CC)(CC)CC(=O)Nc1c(C)cccc1C
InChI
1S/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
InChI key
LLPPOMUAOGMYQI-UHFFFAOYSA-N
生化/生理作用
Lidocaine N-ethyl chloride is an intracellular voltage-gated sodium channel blocker.
其他说明
Stable at room temperature lyophilized. In solution, store at 4 °C for up to two weeks. Store solutions at -20 °C for up to six months.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Michael A Freed
The Journal of physiology, 595(22), 6979-6991 (2017-09-16)
Bipolar and amacrine cells presynaptic to the ON sustained α cell of mouse retina provide currents with a higher signal-to-noise power ratio (SNR) than those presynaptic to the OFF sustained α cell. Yet the ON cell loses proportionately more SNR
Sung-Min Hwang et al.
Biomolecules, 10(11) (2020-11-11)
Local anesthetics (LAs) can completely block nociception by inhibiting voltage-gated sodium channels (VGSCs), and thus, blocking action potentials (APs) within sensory neurons. As one of the several LAs, eugenol is used for dental pain treatment. It reportedly features multiple functions
Mariana Colino-Oliveira et al.
Purinergic signalling, 12(2), 283-294 (2016-02-22)
Brain-derived neurotrophic factor (BDNF) and adenosine are widely recognized as neuromodulators of glutamatergic transmission in the adult brain. Most BDNF actions upon excitatory plasticity phenomena are under control of adenosine A2A receptors (A2ARs). Concerning gamma-aminobutyric acid (GABA)-mediated transmission, the available
Vijay K Samineni et al.
Nature communications, 10(1), 4356-4356 (2019-09-27)
Itch is a distinct aversive sensation that elicits a strong urge to scratch. Despite recent advances in our understanding of the peripheral basis of itch, we know very little regarding how central neural circuits modulate acute and chronic itch processing.
Andrew W Baxter et al.
The European journal of neuroscience, 34(2), 213-220 (2011-07-14)
P2X4 receptors are calcium-permeable cation channels gated by extracellular ATP. They are found close to subsynaptic sites on hippocampal CA1 neurons. We compared features of synaptic strengthening between wild-type and P2X4 knockout mice (21-26 days old). Potentiation evoked by a
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