L3042
左卡巴斯汀 盐酸盐
≥99% (HPLC), solid
别名:
R50547, [3S-[1（顺式），3α，4β]]-1-[4-氰基-4-（4-氟苯基）环己基]-3-甲基-4-苯基-4-哌啶羧酸, 左旋多巴, 立复汀
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关于此项目
经验公式（希尔记法）:
C26H29N2O2F·HCl
CAS Number:
分子量:
456.98
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
方案
≥99% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: soluble ~10 mg/mL
创始人
Johnson & Johnson
SMILES字符串
Cl[H].C[C@@H]1CN(CC[C@]1(C(O)=O)c2ccccc2)[C@@H]3CC[C@@](CC3)(C#N)c4ccc(F)cc4
InChI
1S/C26H29FN2O2.ClH/c1-19-17-29(16-15-26(19,24(30)31)21-5-3-2-4-6-21)23-11-13-25(18-28,14-12-23)20-7-9-22(27)10-8-20;/h2-10,19,23H,11-17H2,1H3,(H,30,31);1H/t19-,23-,25-,26-;/m1./s1
InChI key
OICFWWJHIMKBCD-VALQNVSPSA-N
基因信息
human ... HRH1(3269)
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生化/生理作用
非肽类组胺H1 受体拮抗剂；神经降压素NTS2受体配体。
特点和优势
该化合物由 Johnson & Johnson 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单， 请单击此处。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Srdjan Ante Anzic et al.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 264(11), 1309-1314 (2007-07-10)
Patients with allergic rhinitis demonstrate hyperreactive response in distilled water nasal provocation, shown by significant increase in nasal airway resistance (NAR). Antihistamines, including topical antihistamine, levocabastine, reduce response in non-specific nasal provocation tests. Furosemide is a diuretic which reduces hyperreactivity
Bernd Lange et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 95(3), 272-282 (2005-10-05)
Current guidelines recommend intranasal glucocorticosteroids as first-line therapy for seasonal allergic rhinitis. To compare the efficacy, cost-effectiveness, and tolerability of the topical glucocorticosteroid mometasone furoate, the topical antihistamine levocabastine hydrochloride, and the cromone disodium cromoglycate in seasonal allergic rhinitis. This
Ahmed R Qasem et al.
Biochemical pharmacology, 76(6), 751-762 (2008-08-06)
Levocabastine is an antiallergic drug acting as a histamine H1-receptor antagonist. In allergic conjunctivitis (AC), it may also antagonize up-regulation of the intercellular adhesion molecule-1 (ICAM-1) expressed on epithelial conjunctival cells. However, little is known about its effects on eosinophils
Pascal Tétreault et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(9), 3741-3752 (2013-06-13)
Management of painful peripheral neuropathies remains challenging, since patients with chronic pain respond poorly to the available pharmacopeia. In recent years, the G-protein-coupled receptor neurotensin (NT) type 2 (NTS2) emerged as an attractive target for treating transitory pain states. To
A Schotte et al.
Naunyn-Schmiedeberg's archives of pharmacology, 333(4), 400-405 (1986-08-01)
Levocabastine is a potent antihistamine drug, structurally unrelated to neurotensin. In rat and mouse brain but not in other animal species, it inhibited 60% of the [3H]neurotensin binding displaced by unlabelled neurotensin or neurotensin(8-13). The levocabastine-sensitive site or "site 1"
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