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关于此项目
经验公式(希尔记法):
C26H29N2O2F·HCl
化学文摘社编号:
分子量:
456.98
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Assay:
≥99% (HPLC)
Form:
solid
assay
≥99% (HPLC)
form
solid
color
white
solubility
DMSO: soluble ~10 mg/mL
originator
Johnson & Johnson
SMILES string
Cl[H].C[C@@H]1CN(CC[C@]1(C(O)=O)c2ccccc2)[C@@H]3CC[C@@](CC3)(C#N)c4ccc(F)cc4
InChI
1S/C26H29FN2O2.ClH/c1-19-17-29(16-15-26(19,24(30)31)21-5-3-2-4-6-21)23-11-13-25(18-28,14-12-23)20-7-9-22(27)10-8-20;/h2-10,19,23H,11-17H2,1H3,(H,30,31);1H/t19-,23-,25-,26-;/m1./s1
InChI key
OICFWWJHIMKBCD-VALQNVSPSA-N
Gene Information
human ... HRH1(3269)
Biochem/physiol Actions
非肽类组胺H1 受体拮抗剂;神经降压素NTS2受体配体。
Features and Benefits
该化合物由 Johnson & Johnson 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单, 请单击此处。
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Geneviève Roussy et al.
Molecular pain, 5, 38-38 (2009-07-08)
Central neurotensin (NT) administration results in a naloxone-insensitive antinociceptive response in animal models of acute and persistent pain. Both NTS1 and NTS2 receptors were shown to be required for different aspects of NT-induced analgesia. We recently demonstrated that NTS2 receptors
A Leonardi et al.
The British journal of ophthalmology, 91(12), 1662-1666 (2007-06-23)
This comparative and randomised pilot study assessed the clinical and biological efficacy of Naaxia Sine(R) eye-drops versus levocabastine eye-drops in the treatment of vernal keratoconjunctivitis (VKC). Twenty-three VKC patients were randomised and treated bilaterally for 28 days with N-acetyl-aspartyl-glutamate (NAAGA)
Ahmed R Qasem et al.
Biochemical pharmacology, 76(6), 751-762 (2008-08-06)
Levocabastine is an antiallergic drug acting as a histamine H1-receptor antagonist. In allergic conjunctivitis (AC), it may also antagonize up-regulation of the intercellular adhesion molecule-1 (ICAM-1) expressed on epithelial conjunctival cells. However, little is known about its effects on eosinophils
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L3042-5MG | 04061832091747 |
| L3042-25MG | 04061832091730 |
