一般描述
磷脂酶A1（PLA1）催化卵磷脂Sn-1-位酰基的水解以生成溶血卵磷脂 。它在各种生物中表达，如大鼠血小板、牛脑和睾丸、大黄蜂毒液、鲣鱼肌肉和真菌。编码PLA1的基因为1,056bp的基因组DNA，包括四个外显子和三个短的内含子。成熟蛋白包括269个氨基酸和两个可能的N-糖基化位点（Asn27和Asn55）。
应用
来自米曲霉的磷脂酶A1已被用于：
- 制备sn-1和sn-2 C18:1- 溶血磷脂酰胆碱 (LPC) 区域异构体标准品
- 作为催化剂在微水系统中合成6-O-葡萄糖基-聚(3-羟基链烷酸酯)
- 在连续流微反应器中催化合成丁酸甲酯和苯甲酸甲酯风味酯
- 水解 17:0 磷酸胆碱。
分析说明
最低活性10 KLU/G液体
法律信息
Lecitase is a trademark of Novozymes Corp.
警示用语：
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Specific enrichment of 2-arachidonoyl-lysophosphatidylcholine in carotid atheroma plaque from type 2 diabetic patients
Menegaut L, et al.
Atherosclerosis, 251(1), 339-347 (2016)
S G Monic et al.
Scientific reports, 12(1), 4766-4766 (2022-03-21)
Phospholipases are esterases involved in lipid catabolism. In pathogenic micro-organisms (bacteria, fungi, parasites) they often play a critical role in virulence and pathogenicity. A few phospholipases (PL) have been characterised so far at the gene and protein level in unicellular
Alyssa L Bolen et al.
Journal of lipid research, 52(5), 958-970 (2011-03-12)
Platelet activation initiates an upsurge in polyunsaturated (18:2 and 20:4) lysophosphatidic acid (LPA) production. The biochemical pathway(s) responsible for LPA production during blood clotting are not yet fully understood. Here we describe the purification of a phospholipase A(1) (PLA(1)) from
Jonah E Zarrow et al.
Journal of lipid research, 63(1), 100156-100156 (2021-11-30)
N-acyl-phosphatidylethanolamine (NAPE)-hydrolyzing phospholipase D (NAPE-PLD) is a zinc metallohydrolase enzyme that converts NAPEs to bioactive N-acyl-ethanolamides. Altered NAPE-PLD activity may contribute to pathogenesis of obesity, diabetes, atherosclerosis, and neurological diseases. Selective measurement of NAPE-PLD activity is challenging, however, because of
Thermomyces lanuginosus lipase-catalyzed synthesis of natural flavor esters in a continuous flow microreactor
Gumel AM and Annuar MSM
3 Biotech, 6(1), 24-24 (2016)
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