L5408
LY-171,883
≥98% (TLC)
别名:
5-[4-(4-Acetyl-3-hydroxy-2-propylphenoxy)butyl]-1H-tetrazole, Tomelukast
方案
≥98% (TLC)
SMILES字符串
CCCc1c(O)c(ccc1OCCCCc2nnn[nH]2)C(C)=O
InChI
1S/C16H22N4O3/c1-3-6-13-14(9-8-12(11(2)21)16(13)22)23-10-5-4-7-15-17-19-20-18-15/h8-9,22H,3-7,10H2,1-2H3,(H,17,18,19,20)
InChI key
MWYHLEQJTQJHSS-UHFFFAOYSA-N
生化/生理作用
Selective leukotriene D4 (LTD4) receptor antagonist; PPARα and PPARγ agonist.
警示用语:
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Ingalill Avis et al.
Cancer research, 65(10), 4181-4190 (2005-05-19)
Arachidonic acid (AA) metabolizing enzymes and peroxisome proliferator-activated receptors (PPARs) have been shown to regulate the growth of epithelial cells. We have previously reported that exposure to the 5-lipoxygenase activating protein-directed inhibitor MK886 but not the cyclooxygenase inhibitor, indomethacin, reduced
N L Anderson et al.
Toxicology and applied pharmacology, 137(1), 75-89 (1996-03-01)
We have investigated the effects of five peroxisome proliferators (PPs : clofibric acid, DEHP, WY14,643, nafenopin, and LY171883) on the abundances of a large number of proteins in the livers of treated mice at 5- and 35-day time points. LY171883
Furosemide attenuates bronchial responsiveness to antigen challenge "in vitro".
G Folco et al.
Advances in prostaglandin, thromboxane, and leukotriene research, 23, 365-367 (1995-01-01)
T S Rao et al.
The Journal of pharmacology and experimental therapeutics, 269(3), 917-925 (1994-06-01)
Intraperitoneal administration of zymosan to mice resulted in marked biosynthesis of eicosanoids and influx of neutrophils with distinct time course profiles. 6-Keto-prostaglandin-F1 alpha (6-KPA) increased between 30 and 60 min and rapidly decreased thereafter. Leukotriene (LT)C4 levels showed similar patterns
Common structural requirements for peroxisome proliferation by tetrazole and carboxylic acid-containing compounds.
P I Eacho et al.
Annals of the New York Academy of Sciences, 804, 387-402 (1996-12-27)
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