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Merck
CN

L6004

Sigma-Aldrich

林可霉素 盐酸盐

≥90% (TLC)

别名:

Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside 盐酸盐, 林可霉素 盐酸盐

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关于此项目

经验公式(希尔记法):
C18H34N2O6S · HCl
化学文摘社编号:
分子量:
443.00
Beilstein:
4171650
EC 号:
MDL编号:
UNSPSC代码:
51284507
PubChem化学物质编号:
NACRES:
NA.85
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方案

≥90% (TLC)

效能

800-900 units per mg

颜色

white to faint yellow

溶解性

H2O: soluble 50 mg/mL

抗生素抗菌谱

Gram-positive bacteria

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O

InChI

1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1

InChI key

POUMFISTNHIPTI-BOMBIWCESA-N

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一般描述

化学结构:大环内酯

应用

盐酸林可霉素是一种抗生素,用于研究蛋白质合成抑制、细菌抗生素耐药性以及蛋白质和表面活性剂的结合 它是由 链霉菌 var. Lincolnensis 产生。

生化/生理作用

作用方式:林可霉素可通过在23S rRNA的肽基转移酶环区域内形成交联来抑制细菌蛋白质的合成。†

抗菌谱:盐酸林可霉素对革兰氏阳性菌有效。

制备说明

该产品在水中的溶解度为50 mg/mL,产生澄清无色的溶液。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

蛋白质合成是一个复杂、多步骤过程,涉及到很多酶以及构象排列。但是,阻碍细菌蛋白质合成的大部分抗生素对该过程的干扰发生在70S细菌核糖体的30S亚基或50S亚基。

Antibiotics targeting bacterial ribosomes disrupt protein synthesis, a key process in bacterial growth inhibition.

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