生物来源
mouse
重组
expressed in E. coli
方案
>97% (SDS-PAGE)
表单
lyophilized powder
效能
0.05-0.1 mg per mL ED50 (For chemotaxis of BaF/3 hCXR1 cells)
6-12 mg per mL ED50 (for chemotaxis of Il-2 cultured lymphocytes)
分子量
predicted mol wt ~10 kDa
储存条件
avoid repeated freeze/thaw cycles
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
mouse ... Xcl1(16963)
一般描述
Lymphotactin (XCL1) is generated by activated CD8+ T cells, Th1 (T helper)-polarized CD4+ T cells and NK (natural killer) cells. XCR1 (XC chemokine receptor 1) is a lymphotactin receptor.
生化/生理作用
Lymphotactin (Lptn), a member of the C or γ subfamily of chemokines, is similar to members of the CC and CXC chemokine families, but lacks two of the four cysteine residues. Recombinant mouse lymphotactin has chemotactic activity for lymphocytes, NK cells, and mouse splenocytes, but not for monocytes or neutrophils.
Lymphotactin (XCL1) participates in the formation of lung granuloma. In humans, HIV (human immunodeficiency virus)-1 protein, Tat, upregulates XCL1 expression. Lymphotactin might be involved in the CNS (central nervous system) infiltration of T lymphocytes, leading to HIV-1-mediated neurological diseases.
Member of the C or γ subfamily of chemokines, is similar to members of the CC and CXC chemokine families, but lacks two of the four cysteine residues; has chemotactic activity for lymphocytes, NK cells, and mouse splenocytes, but not for monocytes or neutrophils.
外形
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg bovine serum albumin.
分析说明
The biological activity is measured by its ability to chemoattract 3 week IL-2 cultured human lymphocytes and mouse BaF/3 cells transfected with hXCR1.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
J A Hedrick et al.
Journal of immunology (Baltimore, Md. : 1950), 158(4), 1533-1540 (1997-02-15)
Injection of lymphotactin (Lptn) into the peritoneum caused an influx of lymphocytes at 24 h. Phenotypic analysis of the cellular influx showed that a large proportion of these cells were T lymphocytes; however, a large number of NK cells was
Byung Oh Kim et al.
Journal of immunology (Baltimore, Md. : 1950), 172(3), 1888-1895 (2004-01-22)
HIV-1 Tat has been proposed as a key agent in many AIDS-related disorders, including HIV-1-associated neurological diseases. We have recently shown that Tat expression induces a significant increase in T lymphocytes in the brains of Tat transgenic mice. The CNS
Yu Lei et al.
The Journal of experimental medicine, 208(2), 383-394 (2011-02-09)
Dendritic cells (DCs) in the thymus (tDCs) are predominantly accumulated in the medulla and contribute to the establishment of self-tolerance. However, how the medullary accumulation of tDCs is regulated and involved in self-tolerance is unclear. We show that the chemokine
Adrian G Rosas-Taraco et al.
American journal of respiratory cell and molecular biology, 41(2), 136-145 (2008-12-23)
Mice infected for 60 days with Mycobacterium tuberculosis were treated with aerosolized XCL1-targeting small interfering RNA (siRNA) to induce local and transient suppression of XCL1/lymphotactin (an important chemokine in tuberculoid granuloma formation). The local pulmonary siRNA therapy resulted in a
G S Kelner et al.
Science (New York, N.Y.), 266(5189), 1395-1399 (1994-11-25)
In this study, the cytokine-producing profile of progenitor T cells (pro-T cells) was determined. During screening of a complementary DNA library generated from activated mouse pro-T cells, a cytokine designated lymphotactin was discovered. Lymphotactin is similar to members of both
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