L7009
Prolactin human
recombinant, expressed in E. coli, >97% (SDS-PAGE), lyophilized powder, suitable for cell culture
别名:
LTH, Lactogenic Hormone, Luteotropic Hormone, PRL
重组
expressed in E. coli
描述
200 amino acid residue methionyl form of mature, recombinant human prolactin (amino acid residues 29-227).
无菌性
sterile; 0.2 μm filtered
方案
>97% (SDS-PAGE)
表单
lyophilized powder
分子量
predicted mol wt ~24 kDa
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
UniProt登记号
运输
ambient
储存温度
−20°C
基因信息
human ... PRL(5617)
生化/生理作用
Neuroendocrine hormone; belongs to the cytokine hematopoietic receptor family; induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.
Prolactin is a neuroendocrine hormone. The prolactin receptor is a transmembrane glycoprotein that belongs to the cytokine hematopoietic receptor family. A large number of cells and organs express the receptor, including B cells, T cells, macrophages, monocytes and neutrophils. Prolactin signal transduction involves the JAK/STAT families and the src kinase family. Induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.
外形
Lyophilized from a 0.2 μm filtered solution in 10 mM phosphate and 50 mM NaCl, pH 8.0.
制备说明
It is recommended that sterile 4 mM HCl containing 1 mg/mL bovine serum albumin be added to the vial to prepare a stock solution of no less than 10 μg/mL.
分析说明
Biological activity is measured in a cell proliferation assay using the rat lymphoma, Nb2-11.
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Veronica Zaga-Clavellina et al.
American journal of obstetrics and gynecology, 211(1), 48-48 (2014-02-06)
To test the effect of prolactin (PRL) on expression of proinflammatory cytokines and matrix metallopeptidase 9 (MMP-9) in vitro. Tissue explants were incubated from 4 to 48 hours alone or in the presence of 500 ng/mL PRL, and mRNA expression
Katja Linher-Melville et al.
BMC cancer, 14, 415-415 (2014-06-11)
Liver kinase 1 (LKB1) is an important multi-tasking protein linked with metabolic signaling, also controlling polarity and cytoskeletal rearrangements in diverse cell types including cancer cells. Prolactin (PRL) and Signal transducer and activator of transcription (STAT) proteins have been associated
Tomohiro Yonezawa et al.
Cancer letters, 366(1), 84-92 (2015-06-23)
Controversy exists concerning the role of the long prolactin receptor (PRLR) in the progression of breast cancer. By targeting pre-mRNA splicing, we succeeded in knocking down only the long PRLR in vivo, leaving the short forms unaffected. Using two orthotopic
Alex Man Lai Wu et al.
American journal of physiology. Endocrinology and metabolism, 307(7), E596-E610 (2014-08-15)
The multidrug resistance efflux transporter ATP-binding cassette subfamily G member 2 (ABCG2) is not only overexpressed in certain drug-resistant cancers but is also highly expressed in the mammary gland during lactation, carrying xenobiotics and nutrients into milk. We sought to
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持