L8170
土槿乙酸 B
≥98% (HPLC)
别名:
O-土荆皮甲酸C, 土槿乙酸B, 土槿皮乙酸B
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关于此项目
经验公式（希尔记法）:
C23H28O8
化学文摘社编号:
分子量:
432.46
UNSPSC Code:
12352106
NACRES:
NA.25
MDL number:
InChI
1S/C23H28O8/c1-14(17(24)25)6-5-10-21(2)16-9-12-22(19(27)31-21)11-7-15(18(26)29-3)8-13-23(16,22)20(28)30-4/h5-7,10,16H,8-9,11-13H2,1-4H3,(H,24,25)/b10-5+,14-6+/t16-,21+,22+,23+/m0/s1
SMILES string
O=C(OC)C1=CC[C@@]2(C(O[C@@](/C=C/C=C(C(O)=O)\C)(C)[C@@H]3CC2)=O)[C@]3(OC(C)=O)CC1
InChI key
XRLYZNSOXNPKOR-CBDALDGHSA-N
biological source
Larix kaempferi
assay
≥98% (HPLC)
form
powder or crystals
storage condition
protect from light
color
white to off-white
solubility
methanol: 1 mg/mL, clear, colorless
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
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Biochem/physiol Actions
土槿皮中分离得到天然二萜类化合物土槿皮乙酸B。它已显示出抗真菌，抗生育和抗血管生成特性。它还可能具有抗癌和抗炎特性。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Repr. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Dandan Zhao et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(4), 595-602 (2012-03-06)
Pseudolaric acid B (PAB), a natural diterpene acid present in the traditional Chinese medicinal herb Tu-Jin-Pi, exerted anticancer effects on various cancer cells. However, the effect of PAB on DU145 cells, an in vitro model of hormone-refractory prostate cancer (HRPC)
Jinghua Yu et al.
Journal of pharmacological sciences, 107(3), 295-302 (2008-07-19)
Pseudolaric acid B (PAB) exerted cytostatic activity on murine fibrosarcoma L929 cells. The cytostatic mechanism of PAB on L929 cells was investigated in this paper. At 36 h, after 80 microM PAB treatment, the inhibitory ratio was 65.37 +/- 4.12%
Jing-hua Yu et al.
Acta pharmacologica Sinica, 29(9), 1069-1076 (2008-08-23)
To investigate the apoptotic mechanism of pseudolaric acid B (PAB) in human breast cancer MCF-7 cells. 3-(4,5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide analysis and morphological changes were applied to detect apoptosis. The percentage of apoptotic and necrotic cells were calculated by the lactate
Xia Mai et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(22), 3467-3471 (2013-02-05)
To study the effect of pseudolaric acid B (PLAB) on cell proliferation and cycle of human prostate carcinoma DU-145 cells. method: Its inhibitory effect on the cell growth was measured by MTT method. Characteristics of cell death were determined by
Peng Liu et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 46(11), 1361-1365 (2012-01-21)
The metabolic profile of pseudolaric acid B (PB) was investigated by using in vivo and in vitro tests. Pseudolaric acid C2 (PC2) was identified as the specific metabolite of PB in plasma, urine, bile and feces using HPLC and HPLC-ESI/MS(n)
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