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Merck
CN

L8170

土槿乙酸 B

≥98% (HPLC)

别名:

O-土荆皮甲酸C, 土槿乙酸B, 土槿皮乙酸B

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关于此项目

经验公式（希尔记法）:
C23H28O8
化学文摘社编号:
82508-31-4
分子量:
432.46
UNSPSC Code:
12352106
NACRES:
NA.25
MDL number:
MFCD26960905

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产品名称

土槿乙酸 B, ≥98% (HPLC)

InChI

1S/C23H28O8/c1-14(17(24)25)6-5-10-21(2)16-9-12-22(19(27)31-21)11-7-15(18(26)29-3)8-13-23(16,22)20(28)30-4/h5-7,10,16H,8-9,11-13H2,1-4H3,(H,24,25)/b10-5+,14-6+/t16-,21+,22+,23+/m0/s1

SMILES string

O=C(OC)C1=CC[C@@]2(C(O[C@@](/C=C/C=C(C(O)=O)\C)(C)[C@@H]3CC2)=O)[C@]3(OC(C)=O)CC1

InChI key

XRLYZNSOXNPKOR-CBDALDGHSA-N

biological source

Larix kaempferi

assay

≥98% (HPLC)

form

powder or crystals

storage condition

protect from light

color

white to off-white

solubility

methanol: 1 mg/mL, clear, colorless

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

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Biochem/physiol Actions

土槿皮中分离得到天然二萜类化合物土槿皮乙酸B。它已显示出抗真菌，抗生育和抗血管生成特性。它还可能具有抗癌和抗炎特性。

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBB1866V

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Quan-Bin Han et al.
Journal of separation science, 32(2), 309-313 (2008-12-17)
In order to provide the chemical markers for the quality control of herbal medicines, four diterpenoids, pseudolaric acids A and B (PAA and PAB), and their glucosides were isolated from the methanol extract of the Chinese herb Pseudolarix kaempferi using
Min Qi et al.
European journal of pharmacology, 683(1-3), 16-26 (2012-03-15)
Pseudolaric acid B (PAB) is the primary biologically active compound isolated from the root bark of P. kaempferi Gordon. Previous studies have demonstrated that PAB arrests cells in G2/M phase in several cancer cell lines without significantly perturbing the G2/M
Bing Yu et al.
Journal of molecular medicine (Berlin, Germany), 90(8), 971-981 (2012-03-13)
We have recently discovered that c-Jun executes a non-transcriptional function to stabilize hypoxia inducible factor 1α (HIF-1α) and that pseudolaric acid B (PAB) accelerates HIF-1α degradation and phosphorylates c-Jun at Ser63/73. In this study, PAB was used as a probe
Dandan Zhao et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(4), 595-602 (2012-03-06)
Pseudolaric acid B (PAB), a natural diterpene acid present in the traditional Chinese medicinal herb Tu-Jin-Pi, exerted anticancer effects on various cancer cells. However, the effect of PAB on DU145 cells, an in vitro model of hormone-refractory prostate cancer (HRPC)
Jinghua Yu et al.
Journal of pharmacological sciences, 107(3), 295-302 (2008-07-19)
Pseudolaric acid B (PAB) exerted cytostatic activity on murine fibrosarcoma L929 cells. The cytostatic mechanism of PAB on L929 cells was investigated in this paper. At 36 h, after 80 microM PAB treatment, the inhibitory ratio was 65.37 +/- 4.12%
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