L9787
L-655,708
≥98% (HPLC), powder
别名:
L-655708, （S）-11，12，13，13a-四氢-7-甲氧基-9-氧代-9H-咪唑并[1，5-a]吡咯并[2，1-c][1，4]苯并二氮杂-1-羧酸乙酯
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关于此项目
经验公式（希尔记法）:
C18H19N3O4
化学文摘社编号:
分子量:
341.36
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
powder
溶解性
DMSO: ≥6.0 mg/mL (Warmed)
H2O: insoluble
创始人
Merck & Co., Inc., Kenilworth, NJ, U.S.
SMILES字符串
CCOC(=O)c1ncn2-c3ccc(OC)cc3C(=O)N4CCCC4c12
InChI
1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1
InChI key
YKYOQIXTECBVBB-AWEZNQCLSA-N
基因信息
human ... GABRA5(2558)
应用
L-655，708已被用作α5 GABAA受体反向激动剂，以剂量依赖的方式抑制异丙酚的辨别刺激。
生化/生理作用
L-655，708是 α5 γ-氨基丁酸A型（GABAA）受体的反向激动剂。它具有增加大鼠认知的能力。
含有α5个亚基的GABAA受体苯二氮平类药物位点的配体。
对含有α5个亚基的GABAA 受体的苯二氮平类药物位点具有选择性的新型配体。
特点和优势
该化合物是由Merck & Co., Inc., Kenilworth, NJ, U.S.开发的。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单， 请单击此处。
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储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Jonathan Fischell et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(11), 2499-2509 (2015-04-23)
Selective serotonin reuptake inhibitors (SSRIs) are the primary pharmacological treatment for depression, but SSRIs are effective in only half of the patients and typically take several weeks to relieve symptoms. The NMDA receptor antagonist ketamine exerts a rapid antidepressant action
[3H]L-655,708, a novel ligand selective for the benzodiazepine site of GABAA receptors which contain the α5 subunit.
Quirk, K., et al.
Neuropharmacology, 356, 1331-1335 (1996)
Contribution of the alpha5 GABAA receptor to the discriminative stimulus effects of propofol in rat
Wang B, et al.
Neuroreport, 29(5), 347-347 (2018)
C Sur et al.
Brain research, 822(1-2), 265-270 (1999-03-20)
Multiple subtypes of GABAA receptors are expressed in the rat central nervous system (CNS). To determine the distribution and proportion of alpha5 subunit containing receptors, quantitative autoradiographic analyses were performed with both [3H]L-655,708 and [3H]Ro15-1788, an alpha5 selective and a
José E Hernández-Reyes et al.
Pain, 160(6), 1448-1458 (2019-05-21)
Diabetic neuropathy is an incapacitating complication in diabetic patients. The cellular and molecular mechanisms involved in this pathology are poorly understood. Previous studies have suggested that the loss of spinal GABAergic inhibition participate in painful diabetic neuropathy. However, the role
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