R(+)-甲酰胺

Name: R(+)-甲酰胺
Brand: SIGMA

5 mg/mL in absolute ethanol, ≥96% (HPLC)

别名:

AM-356, R(+)-Arachidonyl-1′-hydroxy-2′-propylamide

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₂₃H₃₉NO₂

CAS Number:

157182-49-5

分子量:

361.56

EC 号:

200-578-6

MDL编号:

MFCD00467914

UNSPSC代码:

12352200

PubChem化学物质编号:

24896698

质量水平

100

方案

≥96% (HPLC)

旋光性

[α]/D +8.7°, c = 4 in chloroform(lit.)

药品控制

regulated under CDSA - not available from Sigma-Aldrich Canada

储存条件

desiccated
protect from light
under inert gas

浓度

5 mg/mL in absolute ethanol

储存温度

−20°C

SMILES字符串

CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)N[C@H](C)CO

InChI

1S/C23H39NO2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-23(26)24-22(2)21-25/h7-8,10-11,13-14,16-17,22,25H,3-6,9,12,15,18-21H2,1-2H3,(H,24,26)/b8-7-,11-10-,14-13-,17-16-/t22-/m1/s1

InChI key

SQKRUBZPTNJQEM-FQPARAGTSA-N

基因信息

mouse ... Cnr1(12801), Cnr2(12802)
rat ... Cnr1(25248)

生化/生理作用

R(+)-Methanandamide is metabolically stable congener of anandamide that has higher affinity for the cannabinoid receptor. Of the analogs tested, (R)-methanandamide exhibited the highest affinity for the cannabinoid receptor with a Ki of 20 +/- 1.6 nM, 4-fold lower than that of anandamide (Ki = 78 +/- 2 nM). (R)-methanandamide exhibits high stability to aminopeptidase hydrolysis. Experiments with mice have demonstrated that (R)-methanandamide also posseses cannabimimetric properties in vivo, as established by the four tests of hypothermia, hypokinesia, ring immobility, and antinociception.

特点和优势

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.