α-(Methylamino)isobutyric acid

Name: α-(Methylamino)isobutyric acid
Brand: SIGMA

≥97% (titration)

别名:

2,N-Dimethylalanine, 2-(Methylamino)-2-methylpropionic acid

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About This Item

线性分子式:

CH₃NHC(CH₃)₂COOH

CAS Number:

2566-34-9

分子量:

117.15

Beilstein:

1746984

EC 号:

219-898-2

MDL编号:

MFCD00004191

UNSPSC代码:

12352209

PubChem化学物质编号:

24896726

NACRES:

NA.26

方案

≥97% (titration)

表单

powder

技术

ligand binding assay: suitable

颜色

white

mp

>300 °C (lit.)

储存温度

−20°C

SMILES字符串

CNC(C)(C)C(O)=O

InChI

1S/C5H11NO2/c1-5(2,6-3)4(7)8/h6H,1-3H3,(H,7,8)

InChI key

DLAMVQGYEVKIRE-UHFFFAOYSA-N

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应用

α-(Methylamino)isobutyric acid (MeAIB) has been used:

as a system A transport system inhibitor to perform inhibition experiments
as a system A transport system inhibitor to study its effect on the generation of epileptiform field potentials (EFPs) in the acutely disinhibited cortical slices
as an N-acetyltransferase (SNAT) inhibitor in Hank′s balanced salt solution (HBSS) to study its influence on the uptake of ¹⁴C-cysteine/ radioactive-labeled cysteine

生化/生理作用

α-(Methylamino)isobutyric acid (MeAIB), a competitive inhibitor of the neutral amino acid transport A system, is an N-methylated substrate. It is capable of decreasing the amplitude of the miniature excitatory postsynaptic current (mEPSC) in hippocampus neurons developing on top of astrocytes. MeAIB can block the alanine-proline (AP) pathway.