M251
Macrophage-Derived Chemokine human
>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
别名:
MDC, STCP-1
生物来源
human
重组
expressed in E. coli
方案
>97% (SDS-PAGE)
表单
lyophilized powder
效能
0.002-0.006 μg/mL ED50
分子量
Mw ~8 kDa
储存条件
avoid repeated freeze/thaw cycles (Storage in "frost-free" freezers is not recommended)
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
human ... CCL22(6367)
生化/生理作用
Macrophage-Derived Chemokine (MDC) induces chemotaxis or calcium mobilization in dendritic cells, IL-2 activated cells, and activated T lymphocytes. MDC, also named stimulated T cell chemotactic protein (STCP-1), shows <35% identity to other CC chemokine family members. It is expressed in dendritic cells, macrophages, and activated monocytes. Expression is also detected in the tissues of thymus, lymph node, and appendix.
外形
Lyophilized from a 0.2 μm filtered solution in 20% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg bovine serum albumin.
分析说明
The biological activity is measured by its ability to chemoattract human T-lymphoblastoid CEM-NKr cells.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
D N Howell et al.
Journal of immunology (Baltimore, Md. : 1950), 134(2), 971-976 (1985-02-01)
The human T lymphoblastoid cell line CEM was subjected to immunoselection by co-culture with peripheral blood mononuclear cells (PBMC) for resistance to natural killer (NK) cell-mediated lysis. The NK susceptibility of the resulting subline, CEM.NKR, was 8.4 to 20.6% of
R Pal et al.
Science (New York, N.Y.), 278(5338), 695-698 (1997-10-24)
CD8(+) T lymphocytes from individuals infected with human immunodeficiency virus-type 1 (HIV-1) secrete a soluble activity that suppresses infection by HIV-1. A protein associated with this activity was purified from the culture supernatant of an immortalized CD8(+) T cell clone
R Godiska et al.
The Journal of experimental medicine, 185(9), 1595-1604 (1997-05-05)
A cDNA encoding a novel human chemokine was isolated by random sequencing of cDNA clones from human monocyte-derived macrophages. This protein has been termed macrophage-derived chemokine (MDC) because it appears to be synthesized specifically by cells of the macrophage lineage.
M s Chang et al.
The Journal of biological chemistry, 272(40), 25229-25237 (1997-10-06)
A novel human chemokine STCP-1 (stimulated T cell chemotactic protein) was isolated from an activated macrophage cDNA library. The chemokine has four cysteines positioned in a manner that identifies STCP-1 as a member of the CC chemokine family. The amino
T Imai et al.
The Journal of biological chemistry, 273(3), 1764-1768 (1998-01-27)
Macrophage-derived chemokine (MDC) is a recently identified member of the CC chemokine family. MDC is not closely related to other chemokines, sharing most similarity with thymus- and activation-regulated chemokine (TARC), which contains 37% identical amino acids. Both chemokines are highly
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