生物来源
human
重组
expressed in E. coli
方案
>97% (SDS-PAGE)
表单
lyophilized powder
效能
0.2-0.6 μg/mL ED50
分子量
Mw ~11.7 kDa
储存条件
avoid repeated freeze/thaw cycles (Storage in "frost-free" freezers is not recommended)
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
human ... CXCL9(4283)
生化/生理作用
MIG, a member of the α (CXC) chemokine family of inflammatory and immunoregulatory cytokines, is a chemoattractant for activated T lymphocytes and TIL, but not for neutrophils or monocytes. The MIG gene is induced in macrophages and primary glial cells of the central nervous system specifically in response to IFN-γ. MIG with large C-terminal deletions have diminished activity in calcium flux assay. The chemokine receptor CXCR3 is specific for MIG and IP-10 and highly expressed in IL-2-activated T-lymphocytes.
外形
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin.
分析说明
The biological activity is measured by its ability to chemoattract human lymphocytes cultured for 8-10 days in the presence of IL-2.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
F Liao et al.
The Journal of experimental medicine, 182(5), 1301-1314 (1995-11-01)
Mig is a chemokine of the CXC subfamily that was discovered by differential screening of a cDNA library prepared from lymphokine-activated macrophages. The mig gene is inducible in macrophages and in other cells in response to interferon (IFN)-gamma. We have
J M Farber
Biochemical and biophysical research communications, 192(1), 223-230 (1993-04-15)
Characterization of lymphokine-activated genes in mouse macrophages led to the identification previously of Mumig, an interferon-gamma-inducible murine gene that encodes a member of the chemokine family of cytokines. The Mumig cDNA probe was used to screen a cDNA library prepared
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