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一般描述
Methoxypolyethylene glycol p-nitrophenyl carbonate is a polyethylene glycol (PEG) derivative. PEGs are widely used as a covalent modifier of biologic macromolecules and particulates and for mechanism of drug delivery.
应用
Methoxypolyethylene glycol p-nitrophenyl carbonate has been used in a study to obtain unimolecular dendritic micelles designed as solubility enhancers. It has also been used in a study to investigate the properties of lipase from Candida rugosa modified with Mpeg. It is also useful for modification of proteins.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Properties of methoxy(polyethylene glycol)-lipase from Candida rugosa in organic solvents
Zacchigna, M., et al.
Il Farmaco Ed. Sc., 53, 758-758 (1998)
Hu Yang et al.
Journal of colloid and interface science, 273(1), 148-154 (2004-03-31)
Unimolecular dendritic micelles designed as solubility enhancers were obtained by coupling polyethylene glycol (PEG) to Starburst polyamidoamine (PAMAM) dendrimers. Micelles-750, -2000, and -5000 have a generation 3.0 dendrimer core (32 primary amine end groups) and PEG arms with molecular weights
Chemistry of polyethylene glycol conjugates with biologically active molecules
Zalipsky, S., et al.
Advanced Drug Delivery Reviews, 16, 157-157 (1995)
F M Veronese et al.
Applied biochemistry and biotechnology, 11(2), 141-152 (1985-04-01)
A single-step method of activation of monomethoxypolyethylene glycols suitable for its binding to polypeptides and proteins is proposed. Based on the reaction with 2,4,5-trichlorophenylchloroformate or p-nitrophenylchloroformate, it gives reactive PEG-phenylcarbonate derivatives. The PEG intermediate is stable on storage, the activating
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