M4008
桑色素 水合物
antioxidant, powder
别名:
2′,3,4′,5,7-五羟黄酮
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关于此项目
经验公式（希尔记法）:
C15H10O7 · xH2O
化学文摘社编号:
分子量:
302.24 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12171500
EC Number:
207-542-9
MDL number:
产品名称
桑色素 水合物, powder
InChI key
MYUBTSPIIFYCIU-UHFFFAOYSA-N
InChI
1S/C15H10O7.H2O/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15;/h1-5,16-19,21H;1H2
SMILES string
O.Oc1ccc(c(O)c1)C2=C(O)C(=O)c3c(O)cc(O)cc3O2
form
powder
color
yellow
solubility
methanol: 50 mg/mL
Quality Level
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相关类别
Application
桑色素曾被用于：
- 在人癌细胞系中利用细胞活性和凋亡检测探讨其抗肿瘤功能。
- 作为荧光染料检测运动神经元和腰髓中的铝。
- 研究其对神经元性听力损失及对神经干细胞 (NSC) 增殖分化的保护作用
Biochem/physiol Actions
桑色素是一种具有抗氧化属性黄酮类化合物。它已被证明可以保护细胞免受氧自由基的损害。桑色素不仅能清除氧自由基，还能适度抑制黄嘌呤氧化酶（一种产生自由基的酶）。在 75-100 微摩尔浓度时，桑色素抑制自由基或 Cu 2 + 对低密度脂蛋白 (LDL) 的氧化 。据报道，桑色素在体外和体内能够抑制大鼠脑磷酸肌醇磷酸酯激酶活性。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
T W Wu et al.
Biochemical pharmacology, 49(4), 537-543 (1995-02-14)
Morin hydrate is a bioactive pigment found in yellow Brazil wood. Recently, we reported that morin hydrate prolongs the survival of three types of cells from the human circulatory system against oxyradicals generated in vitro. The protection excels that given
T W Wu et al.
Life sciences, 58(2), PL 17-PL 22 (1996-01-01)
We demonstrated that the flavonoid morin hydrate at 75-100 microM protects against the oxidation of low density lipoprotein (LDL) by free radicals produced by 2,2'-azo-bis(2-amidinopropane) dihydrochloride. Morin hydrate reduces the relative electrophoretic mobility, malondialdehyde equivalents and lipid peroxide level of
Christopher A Shaw et al.
Journal of inorganic biochemistry, 103(11), 1555-1562 (2009-09-11)
Gulf War Syndrome is a multi-system disorder afflicting many veterans of Western armies in the 1990-1991 Gulf War. A number of those afflicted may show neurological deficits including various cognitive dysfunctions and motor neuron disease, the latter expression virtually indistinguishable
Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration
Shaw CA and Petrik MS
Journal of Inorganic Biochemistry, 103(11), 1555-1562 (2009)
L H Zeng et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 75(6), 717-720 (1997-01-01)
Oxygen-derived free radicals are known to injure the endothelium of aorta in diverse disorders. In this study we compared the cytoprotective effects of three flavonoids against oxyradical damage to porcine aortic endothelial cells in vitro. Cultured porcine aortic endothelial cells
商品
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。
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