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Merck
CN

M4154

β-N-Methylamino-L-alanine hydrochloride

别名:

L-BMAA

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关于此项目

经验公式(希尔记法):
C4H10N2O2 · HCl
化学文摘社编号:
分子量:
154.60
UNSPSC Code:
12352200
MDL number:
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SMILES string

CNCC(N)C(O)=O

storage temp.

2-8°C

Biochem/physiol Actions

Neuroexcitotoxic amino acid; may be involved in Guam amyotrophic lateral sclerosis

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

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Steven A Cohen
The Analyst, 137(9), 1991-2005 (2012-03-17)
The non-protein amino acid L-α-amino-β-methylaminopropionic acid (BMAA) has been linked to several neurodegenerative diseases. Its presence in trace amounts in complex sample such as bacterial, plant and mammalian tissue extracts and hydrolyzates makes analysis a complicated process requiring good analytical
Estefanía de Munck et al.
Environmental toxicology and pharmacology, 35(2), 193-199 (2013-01-19)
β-N-methylamino-(L)-alanine (L)-BMAA) is a neurotoxic amino acid, found in the majority of cyanbacterial genera tested. Evidence for implication of (L)-BMAA in neurodegenerative disorders, like amyotrophic lateral sclerosis (ALS), relies on bioaccumulation and biomagnification from symbiotic cyanobacteria. The involvement of (L)-BMAA
Oskar Karlsson et al.
Toxicological sciences : an official journal of the Society of Toxicology, 130(2), 391-404 (2012-08-09)
The cyanobacterial toxin β-N-methylamino-L-alanine (BMAA) has been proposed to contribute to neurodegenerative disease. We have previously reported a selective uptake of BMAA in the mouse neonatal hippocampus and that exposure during the neonatal period causes learning and memory impairments in
J S Metcalf et al.
Chemosphere, 90(2), 835-839 (2012-11-06)
The Lesser Flamingo (Phoeniconaias minor) is known to use cyanobacteria (primarily Arthrospira) as a major food source in the East African Rift Valley lakes. Periodically, mass mortalities have occurred, associated with the cyanobacterial toxins (cyanotoxins), microcystins and anatoxin-a. Deposition of
Kiyo Mondo et al.
Marine drugs, 10(2), 509-520 (2012-03-14)
Sharks are among the most threatened groups of marine species. Populations are declining globally to support the growing demand for shark fin soup. Sharks are known to bioaccumulate toxins that may pose health risks to consumers of shark products. The

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