M5046
(±)-α-Methyl-(4-sulfonophenyl)glycine
别名:
MSPG
储存温度
2-8°C
SMILES字符串
CC(N)(C(O)=O)c1ccc(cc1)S(O)(=O)=O
InChI
1S/C9H11NO5S/c1-9(10,8(11)12)6-2-4-7(5-3-6)16(13,14)15/h2-5H,10H2,1H3,(H,11,12)(H,13,14,15)
InChI key
MVDSFPIEJILRME-UHFFFAOYSA-N
生化/生理作用
Antagonist at Group III metabotropic glutamate receptors.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Ivana Pulić et al.
Journal of structural biology, 194(2), 147-155 (2016-02-13)
Flagellin component D (FlgD) participates in the assembly of flagella, helical tubular structures that provide motility in non-filamentous bacteria. FlgD guides and controls the polymerization of FlgE that builds the hook, a short curved and hollow cylinder that connects the
Ersin Yavas et al.
ACS chemical neuroscience, 8(2), 320-328 (2017-01-26)
The N-methyl-d-aspartate (NMDA) receptor antagonist, phencyclidine, induces behavioral changes in rodents mimicking symptoms of schizophrenia, possibly mediated through dysregulation of glutamatergic control of mesolimbic dopamine release. We tested the hypothesis that NMDA receptor activation modulates accumbens dopamine release, and that
Lorenzo Caputi et al.
Nature chemical biology, 16(4), 383-386 (2020-02-19)
Cycloaddition reactions generate chemical complexity in a single step. Here we report the crystal structures of three homologous plant-derived cyclases involved in the biosynthesis of iboga and aspidosperma alkaloids. These enzymes act on the same substrate, named angryline, to generate
D E Jane et al.
Neuropharmacology, 34(8), 851-856 (1995-08-01)
The depression of the monosynaptic excitation of neonatal rat motoneurones produced by the metabotropic glutamate receptor (mGluR) agonists (1S,3S)-1-aminocyclopentane-1, 3-dicarboxylate (ACPD) or L-2-amino-4-phosphonobutyrate (L-AP4) was antagonized by three novel phenylglycine analogues: (RS)-alpha-methyl-4-sulphonophenylglycine (MSPG), (RS)-alpha-methyl-4-phosphonophenylglycine (MPPG) and (RS)-alpha-methyl-4-tetrazolylphenylglycine (MTPG). The potencies
J S Bedingfield et al.
European journal of pharmacology, 309(1), 71-78 (1996-08-01)
The metabotropic glutamate (mGlu) receptor antagonist properties of novel phenylglycine analogues were investigated in adult rat cortical slices (mGlu receptors negatively coupled to adenylyl cyclase), neonatal rat cortical slices and in cultured rat cerebellar granule cells (mGlu receptors coupled to
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