M5269
Moniliformin sodium salt
from Fusarium proliferatum, tricarboxylic acid (TCA) cycle oxidation inhibitor
别名:
1-Hydroxycyclobut-1-ene-3,4-dione
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线性分子式:
C4HO3Na
化学文摘社编号:
分子量:
120.04
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Quality level:
产品名称
Moniliformin sodium salt from Fusarium proliferatum,
SMILES string
O=C1C(C=C1[O-])=O.[Na+]
InChI
1S/C4H2O3.Na/c5-2-1-3(6)4(2)7;/h1,5H;/q;+1/p-1
InChI key
FERDNJVXTWPNSA-UHFFFAOYSA-M
storage temp.
2-8°C
Quality Level
Application
Moniliformin sodium salt from Fusarium proliferatum has been used as a mycotoxin standard:
- to test its acute oral toxicity in mice
- to test its subacute toxic effects in rats
- in characterizing mycotoxins from Aspergillus
Biochem/physiol Actions
Moniliformin (MON) is implicated for its toxic potential and may lead to respiratory distress and progressive muscular weakness in rats. It inhibits the tricarboxylic acid (TCA) cycle oxidation step. By acting as a pyruvate substrate, MON effectively inhibits thiamine pyrophosphate cofactor dependant enzymes and blocks the gluconeogenesis pathway. ) Furthermore, MON also inhibits glutathione peroxidase and glutathione reductase leading to oxidative stress in myoblast.
General description
Moniliformin (MON), a mycotoxin and small ionic molecule, is present in various Fusarium species including Fusarium avenaceum, Fusarium subglutinans and Fusarium proliferatum. It is present as sodium or potassium salt of semisquaric acid naturally. MON is also present in maize and small-grain cereals.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
高风险级别生物产品--毒素类产品
此项目有
H R Burmeister et al.
Applied and environmental microbiology, 37(1), 11-13 (1979-01-01)
Fusarium moniliforme NRRL 6322 produced about 600 mg of recoverable moniliformin, a mycotoxic metabolite, per kg of corn grit medium. The moniliformin was extracted from the grits with methanol, purified by preparative thin-layer chromatography, and crystallized from ether. The 50%
Martina Jonsson et al.
Toxicology letters, 233(1), 38-44 (2014-12-09)
Moniliformin is a Fusarium mycotoxin mainly produced by several species infecting grains in different climatic conditions. According to our previous studies, it is acutely toxic to rats, with an LD50 cut-off value of 25mg/kg b.w. To further assess the possible
Katharina Walburga von Bargen et al.
Journal of agricultural and food chemistry, 60(14), 3586-3591 (2012-03-21)
Moniliformin is a mycotoxin produced by fungi of the Fusarium genus and occurs as a contaminant of different cereals worldwide. This study describes the first application of isotopically labeled (13)C(2)-moniliformin for the analysis of moniliformin in cereals. Moniliformin is a
An Zhang et al.
Journal of Zhejiang University. Science. B, 11(3), 200-208 (2010-03-06)
To investigate the effects of mycotoxin moniliformin (MON) on the metabolism of aggrecan and type II collagen in human chondrocytes in vitro and the relationship between MON and Kashin-Beck disease (KBD). Human chondrocytes were isolated and cultured on bone matrix
D Sharma et al.
Poultry science, 87(6), 1039-1051 (2008-05-22)
A total of 390 one-day-old quail chicks (Coturnix coturnix japonica) were divided into 4 groups (3 replicates per treatment), viz. CX, FX, MX, and FM, containing 75, 105, 105, and 105 birds, respectively. Birds in the control group (CX) were
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