M5269
Moniliformin sodium salt
from Fusarium proliferatum, tricarboxylic acid (TCA) cycle oxidation inhibitor
别名:
1-Hydroxycyclobut-1-ene-3,4-dione
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关于此项目
线性分子式:
C4HO3Na
化学文摘社编号:
分子量:
120.04
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Moniliformin sodium salt from Fusarium proliferatum,
Quality Segment
storage temp.
2-8°C
SMILES string
O=C1C(C=C1[O-])=O.[Na+]
InChI
1S/C4H2O3.Na/c5-2-1-3(6)4(2)7;/h1,5H;/q;+1/p-1
InChI key
FERDNJVXTWPNSA-UHFFFAOYSA-M
General description
Moniliformin (MON), a mycotoxin and small ionic molecule, is present in various Fusarium species including Fusarium avenaceum, Fusarium subglutinans and Fusarium proliferatum. It is present as sodium or potassium salt of semisquaric acid naturally. MON is also present in maize and small-grain cereals.
Application
Moniliformin sodium salt from Fusarium proliferatum has been used as a mycotoxin standard:
- to test its acute oral toxicity in mice
- to test its subacute toxic effects in rats
- in characterizing mycotoxins from Aspergillus
Biochem/physiol Actions
Moniliformin (MON) is implicated for its toxic potential and may lead to respiratory distress and progressive muscular weakness in rats. It inhibits the tricarboxylic acid (TCA) cycle oxidation step. By acting as a pyruvate substrate, MON effectively inhibits thiamine pyrophosphate cofactor dependant enzymes and blocks the gluconeogenesis pathway. ) Furthermore, MON also inhibits glutathione peroxidase and glutathione reductase leading to oxidative stress in myoblast.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges