M6316
MRS 1754 hydrate
≥98% (HPLC), solid
别名:
8-[4-[((4-Cyanophenyl)carbamoylmethyl)oxy]phenyl]-1,3-di(n-propyl)xanthine hydrate
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关于此项目
经验公式（希尔记法）:
C26H26N6O4 · xH2O
化学文摘社编号:
分子量:
486.52 (anhydrous basis)
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality Segment
assay
≥98% (HPLC)
form
solid
color
off-white
solubility
DMSO: soluble >10 mg/mL
storage temp.
room temp
SMILES string
O.CCCN1C(=O)N(CCC)c2[nH]c(nc2C1=O)-c3ccc(OCC(=O)Nc4ccc(cc4)C#N)cc3
InChI
1S/C26H26N6O4.H2O/c1-3-13-31-24-22(25(34)32(14-4-2)26(31)35)29-23(30-24)18-7-11-20(12-8-18)36-16-21(33)28-19-9-5-17(15-27)6-10-19;/h5-12H,3-4,13-14,16H2,1-2H3,(H,28,33)(H,29,30);1H2
InChI key
ZACJDWOPQROWIK-UHFFFAOYSA-N
Gene Information
human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316)
Application
MRS 1754 hydrate has been used as an adenosine receptor A2B (RA2B) antagonist:
- to study its effects on endothelial nitric oxide synthase (eNOS) phosphorylation induced by short-term acetate stimulation in human umbilical vein endothelial cells (HUVECs)
- blastema formation in zebrafish
- to serve as a positive control in the anti-sickling assay and to study the role of RA2B in the same
Biochem/physiol Actions
MRS 1754 hydrate is a p-cyanoanilide xanthine derivative. It might act as a potential anti-asthmatic drug.
MRS 1754 hydrate is a potent A2B adenosine receptor antagonist.
Features and Benefits
This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Legal Information
Manufactured and sold under license from Adenosine Therapeutics LLC.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)