M8057
p38 MAP Kinase, Non-Activated human
≥90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine-tagged), buffered aqueous glycerol solution
别名:
SAPK2a, Stress activated protein kinase 2α
重组
expressed in E. coli (N-terminal histidine-tagged)
方案
≥90% (SDS-PAGE)
表单
buffered aqueous glycerol solution
分子量
38 kDa
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... MAPK14(1432)
生化/生理作用
p38 MAP kinase (RK, SAPK2a, Mxi2, CSBP) is an enzyme that belongs to the MAP kinase family of proteins which are activated by dual phosphorylation on tyrosine and serine residues. p38 MAP kinase is homologous to the Saccharomyces cerevisiae HOG1 protein and represents a signal transduction pathway distinct from the ERK1/ERK2 pathway and JNK pathways. Activation of p38 MAP kinase occurs in response to heat shock, osmotic stress, UV irradiation and exposure to sodium arsenite or lipopolysaccharides. p38 MAP kinase is activated by the dual specificity kinases, i.e. MKK3, MKK4 or MKK6, and subsequently phosphorylates downstream substrates such as the transcription factor ATF2 and the protein kinases MAPKAP kinase-2 and MAPKAP kinase-3.
外形
Solution in 20 mM Tris buffer, pH 7.4, containing 50 mM sodium chloride, 0.5 mM EGTA, 1 mM DTT, 10% glycerol (w/v) and 0.03% Brij 35
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
J Han et al.
The Journal of biological chemistry, 271(6), 2886-2891 (1996-02-09)
Mitogen-activated protein (MAP) kinases require dual phosphorylation on threonine and tyrosine residues in order to gain enzymatic activity. This activation is carried out by a family of enzymes known as MAP kinase kinases (MKKs or MEKs). It appears that there
A Cuenda et al.
The EMBO journal, 16(2), 295-305 (1997-01-15)
Stress-activated protein kinase-3 (SAPK3), a recently described MAP kinase family member with a wide-spread tissue distribution, was transfected into several mammalian cell lines and shown to be activated in response to cellular stresses, interleukin-1 (IL-1) and tumour necrosis factor (TNF)
B Dérijard et al.
Science (New York, N.Y.), 267(5198), 682-685 (1995-02-03)
Mammalian mitogen-activated protein (MAP) kinases include extracellular signal-regulated protein kinase (ERK), c-Jun amino-terminal kinase (JNK), and p38 subgroups. These MAP kinase isoforms are activated by dual phosphorylation on threonine and tyrosine. Two human MAP kinase kinases (MKK3 and MKK4) were
J Raingeaud et al.
The Journal of biological chemistry, 270(13), 7420-7426 (1995-03-31)
Protein kinases activated by dual phosphorylation on Tyr and Thr (MAP kinases) can be grouped into two major classes: ERK and JNK. The ERK group regulates multiple targets in response to growth factors via a Ras-dependent mechanism. In contrast, JNK
J Han et al.
Science (New York, N.Y.), 265(5173), 808-811 (1994-08-05)
Mammalian cells respond to endotoxic lipopolysaccharide (LPS) by activation of protein kinase cascades that lead to new gene expression. A protein kinase, p38, that was tyrosine phosphorylated in response to LPS, was cloned. The p38 enzyme and the product of
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