生物来源
goat
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
种属反应性
mouse
技术
indirect ELISA: 0.5-1.0 μg/mL
neutralization: suitable
western blot: 0.1-0.2 μg/mL
UniProt登记号
储存温度
−20°C
基因信息
mouse ... Csf1(12977)
一般描述
Macrophage Colony Stimulating Factor (M-CSF) is a cytokine that plays a crucial role in host response to viral and fungal infections. It is secreted by fibroblasts, monocytes/macrophages and epithelial cells. M-CSF has been reported to the growth and differentiation of monocytes/macrophages. The M-CSF levels increase rapidly in response to fungal infections by Candida albicans and Aspergillus fumigatus. Reports suggest that M-CSF may act in an autocrine/paracrine manner to sustain HIV replication and increase the frequency by which the macrophages become infected with the virus. M-CSF may be a treatment option to combat infections associated with neutropenia. Anti-Macrophage Colony Stimulating Factor antibody specifically reacts with mouse M-CSF. The antibody shows approximately 5% cross-reactivity with recombinant human M-CSF.
免疫原
recombinant mouse M-CSF expressed in Escherichia coli.
应用
Anti-Macrophage Colony Stimulating Factor antibody may be used for ELISA at a working antibody concentration of 0.5-1.0 μg/ml. For immunoblotting the recommended concentration is 0.1-0.2 μg/ml. It is also suitable to neutralize the biological activity of mouse M-CSF in neutralization assays at a working concentration of 0.015-0.035 μg/ml. The antibody was used to neutralize M-CSF of murine embryonic fibroblasts.
生化/生理作用
By immunoblotting and ELISA, the antibody shows 5% cross-reactivity with recombinant human M-CSF.
外形
Lyophilized from a 0.2 μm-filtered solution of phosphate-buffered saline.
未找到合适的产品？
试试我们的产品选型工具.
法规信息
新产品
此项目有
Tamara Muliaditan et al.
Cell reports. Medicine, 2(12), 100457-100457 (2022-01-15)
Second generation (2G) chimeric antigen receptors (CARs) contain a CD28 or 41BB co-stimulatory endodomain and elicit remarkable efficacy in hematological malignancies. Third generation (3G) CARs extend this linear blueprint by fusing both co-stimulatory units in series. However, clinical impact has
Macrophage function activating cytokines: potential clinical application
Neumunaitis J
Critical Reviews in Oncology/Hematology, 14, 153-171 (1993)
M F Gruber et al.
Journal of immunology (Baltimore, Md. : 1950), 154(10), 5528-5535 (1995-05-15)
Human monocyte-derived macrophages (MDM) cultured in medium containing macrophage (M) CSF are more susceptible to infection with HIV-1. M-CSF increases the frequency with which MDM become infected, the level of HIV mRNA expressed per infected cell, and the level of
E Cenci et al.
Infection and immunity, 59(3), 868-872 (1991-03-01)
Serum and tissue concentrations of the macrophage-specific colony-stimulating factor (CSF-1) and the number of CSF-1-responsive cells in bone marrow were investigated in mice chronically infected with a low-virulence strain of the opportunistic zoopathogenic yeast Candida albicans. CSF-1 levels in serum
E Roilides et al.
The Journal of infectious diseases, 172(4), 1028-1034 (1995-10-01)
The effects of recombinant human macrophage colony-stimulating factor (M-CSF) on antifungal activity of human monocytes (MNC), MNC-derived macrophages (MDM), and rabbit pulmonary alveolar macrophages (PAM) against Aspergillus fumigatus were studied. MNC-induced hyphal damage was augmented by incubation with M-CSF (P
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持