M9182
Anti-Macrophage Colony Stimulating Factor antibody produced in goat
affinity isolated antibody, lyophilized powder
别名:
Anti-M-CSF
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse
technique(s)
indirect ELISA: 0.5-1.0 μg/mL, neutralization: suitable, western blot: 0.1-0.2 μg/mL
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Csf1(12977)
General description
Macrophage Colony Stimulating Factor (M-CSF) is a cytokine that plays a crucial role in host response to viral and fungal infections. It is secreted by fibroblasts, monocytes/macrophages and epithelial cells. M-CSF has been reported to the growth and differentiation of monocytes/macrophages. The M-CSF levels increase rapidly in response to fungal infections by Candida albicans and Aspergillus fumigatus. Reports suggest that M-CSF may act in an autocrine/paracrine manner to sustain HIV replication and increase the frequency by which the macrophages become infected with the virus. M-CSF may be a treatment option to combat infections associated with neutropenia. Anti-Macrophage Colony Stimulating Factor antibody specifically reacts with mouse M-CSF. The antibody shows approximately 5% cross-reactivity with recombinant human M-CSF.
Immunogen
recombinant mouse M-CSF expressed in Escherichia coli.
Application
Anti-Macrophage Colony Stimulating Factor antibody may be used for ELISA at a working antibody concentration of 0.5-1.0 μg/ml. For immunoblotting the recommended concentration is 0.1-0.2 μg/ml. It is also suitable to neutralize the biological activity of mouse M-CSF in neutralization assays at a working concentration of 0.015-0.035 μg/ml. The antibody was used to neutralize M-CSF of murine embryonic fibroblasts.
Biochem/physiol Actions
By immunoblotting and ELISA, the antibody shows 5% cross-reactivity with recombinant human M-CSF.
Physical form
Lyophilized from a 0.2 μm-filtered solution of phosphate-buffered saline.
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Tamara Muliaditan et al.
Cell reports. Medicine, 2(12), 100457-100457 (2022-01-15)
Second generation (2G) chimeric antigen receptors (CARs) contain a CD28 or 41BB co-stimulatory endodomain and elicit remarkable efficacy in hematological malignancies. Third generation (3G) CARs extend this linear blueprint by fusing both co-stimulatory units in series. However, clinical impact has
Macrophage function activating cytokines: potential clinical application
Neumunaitis J
Critical Reviews in Oncology/Hematology, 14, 153-171 (1993)
Hui Hua Zhang et al.
Journal of leukocyte biology, 82(4), 915-925 (2007-07-27)
G-CSF and GM-CSF play important roles in regulating neutrophil production, survival, differentiation, and function. However, we have shown previously that G-CSF/GM-CSF double-deficient [knockout (KO)] mice still develop a profound neutrophilia in bone marrow and blood after infection with Candida albicans.
E Roilides et al.
The Journal of infectious diseases, 172(4), 1028-1034 (1995-10-01)
The effects of recombinant human macrophage colony-stimulating factor (M-CSF) on antifungal activity of human monocytes (MNC), MNC-derived macrophages (MDM), and rabbit pulmonary alveolar macrophages (PAM) against Aspergillus fumigatus were studied. MNC-induced hyphal damage was augmented by incubation with M-CSF (P
M F Gruber et al.
Journal of immunology (Baltimore, Md. : 1950), 154(10), 5528-5535 (1995-05-15)
Human monocyte-derived macrophages (MDM) cultured in medium containing macrophage (M) CSF are more susceptible to infection with HIV-1. M-CSF increases the frequency with which MDM become infected, the level of HIV mRNA expressed per infected cell, and the level of
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