M9766
4-甲基伞形酮 α- D -吡喃葡萄糖苷
α-glucosidase substrate, fluorogenic, ≥99% (TLC), powder
别名:
4-甲基伞形酮 α- D -葡萄糖苷
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关于此项目
经验公式（希尔记法）:
C16H18O8
化学文摘社编号:
分子量:
338.31
Beilstein:
1690776
EC 号:
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.32
产品名称
4-甲基伞形酮 α- D -吡喃葡萄糖苷, α-glucosidase substrate
质量水平
描述
α-glucosidase substrate
方案
≥99% (TLC)
表单
powder
溶解性
pyridine: 50 mg/mL, clear, colorless to faintly yellow
储存温度
−20°C
SMILES字符串
CC1=CC(=O)Oc2cc(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc12
InChI
1S/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15-,16+/m1/s1
InChI key
YUDPTGPSBJVHCN-JZYAIQKZSA-N
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应用
4-甲基伞形基ǥ-D-吡喃葡糖苷已用于测定组织匀浆中的酸性 α-葡萄糖苷酶（GAA）活性。
生化/生理作用
4-甲基伞形基ǥ-D-吡喃葡糖苷是 ǥ-葡萄糖苷酶的荧光底物。产物 4-甲基伞形花酯在荧光光谱中显示出 440nm 处的峰值。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Omid Motabar et al.
Analytical biochemistry, 390(1), 79-84 (2009-04-18)
Mutations in alpha-glucosidase cause accumulation of glycogen in lysosomes, resulting in Pompe disease, a lysosomal storage disorder. Small molecule chaperones that bind to enzyme proteins and correct the misfolding and mistrafficking of mutant proteins have emerged as a new therapeutic
Intrapleural administration of AAV9 improves neural and cardiorespiratory function in Pompe disease.
Darin J Falk et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 21(9), 1661-1667 (2013-06-05)
Pompe disease is a neuromuscular disease resulting from deficiency in acid α-glucosidase (GAA), results in cardiac, skeletal muscle, and central nervous system (CNS) pathology. Enzyme replacement therapy (ERT) has been shown to partially correct cardiac and skeletal muscle dysfunction. However
Phillip A Doerfler et al.
Human gene therapy, 27(1), 43-59 (2015-11-26)
Pompe disease is a progressive neuromuscular disorder caused by lysosomal accumulation of glycogen from a deficiency in acid alpha-glucosidase (GAA). Replacement of the missing enzyme is available by repeated protein infusions; however, efficacy is limited by immune response and inability
Ryoga Hamura et al.
Cancer science, 112(6), 2335-2348 (2021-05-02)
Lysosomal degradation plays a crucial role in the metabolism of biological macromolecules supplied by autophagy. The regulation of the autophagy-lysosome system, which contributes to intracellular homeostasis, chemoresistance, and tumor progression, has recently been revealed as a promising therapeutic approach for
J E Magyar et al.
The international journal of biochemistry & cell biology, 41(3), 694-700 (2008-09-04)
It has been recently reported that tea flavanols, including epigallocatechin gallate (EGCG), efficiently inhibit glucosidase II in liver microsomes. Since glucosidase II plays a central role in glycoprotein processing and quality control in the endoplasmic reticulum we investigated the possible
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