Name: Naloxone methiodide
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₂₀H₂₄INO₄

CAS Number:

93302-47-7

分子量:

469.31

MDL编号:

MFCD00078592

UNSPSC代码:

12352200

PubChem化学物质编号:

24897480

NACRES:

NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

solid

药品控制

regulated under CDSA - not available from Sigma-Aldrich Canada

颜色

white to tan

溶解性

H₂O: >10 mg/mL

储存温度

2-8°C

SMILES字符串

[I-].[H][C@]12Oc3c(O)ccc4C[C@@H]5[C@](O)(CCC1=O)[C@@]2(CC[N@+]5(C)CC=C)c34

InChI

1S/C20H23NO4.HI/c1-3-9-21(2)10-8-19-16-12-4-5-13(22)17(16)25-18(19)14(23)6-7-20(19,24)15(21)11-12;/h3-5,15,18,24H,1,6-11H2,2H3;1H/t15-,18+,19+,20-,21?;/m1./s1

InChI key

ICONPJDAXITIPI-UXYWFNEESA-N

应用

Naloxone methiodide has been used as inhibitor of opioid receptor in fish and mice. Naloxone methiodide has been used to block opioid neurotransmission.

生化/生理作用

Naloxone methiodide has low affinity for opioid receptors than naloxone. Administration of naloxone inhibits opioid receptor and opioid-induced respiratory depression.

Quaternary salt of naloxone that, like the parent compound, is a nonselective antagonist at opioid receptors. It does not cross the blood-brain barrier.