N129
Naloxone methiodide
≥98% (HPLC), opioid receptor inhibitor, solid
别名:
(5α,17R)-4,5-Epoxy-3,14-dihydroxy-17-methyl-6-oxo-17-(2-propenyl)-morphinanium iodide, N-Methylnaloxonium iodide
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关于此项目
经验公式（希尔记法）:
C20H24INO4
化学文摘社编号:
分子量:
469.31
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
Naloxone methiodide, ≥98% (HPLC), solid
质量水平
方案
≥98% (HPLC)
表单
solid
药品控制
regulated under CDSA - not available from Sigma-Aldrich Canada
颜色
white to tan
溶解性
H2O: >10 mg/mL
储存温度
2-8°C
SMILES字符串
[I-].[H][C@]12Oc3c(O)ccc4C[C@@H]5[C@](O)(CCC1=O)[C@@]2(CC[N@+]5(C)CC=C)c34
InChI
1S/C20H23NO4.HI/c1-3-9-21(2)10-8-19-16-12-4-5-13(22)17(16)25-18(19)14(23)6-7-20(19,24)15(21)11-12;/h3-5,15,18,24H,1,6-11H2,2H3;1H/t15-,18+,19+,20-,21?;/m1./s1
InChI key
ICONPJDAXITIPI-UXYWFNEESA-N
应用
Naloxone methiodide has been used as inhibitor of opioid receptor in fish and mice. Naloxone methiodide has been used to block opioid neurotransmission.
生化/生理作用
Naloxone methiodide has low affinity for opioid receptors than naloxone. Administration of naloxone inhibits opioid receptor and opioid-induced respiratory depression.
Quaternary salt of naloxone that, like the parent compound, is a nonselective antagonist at opioid receptors. It does not cross the blood-brain barrier.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Lorella Pasquinucci et al.
European journal of pharmacology, 847, 97-102 (2019-01-29)
Development of new analgesics endowed with mu/delta opioid receptor (MOR/DOR) activity represents a promising alternative to MOR selective compounds because of their better therapeutic and tolerability profile. Lately, we have synthetized the MOR/DOR agonist LP2 that showed a long lasting
R J Milne et al.
Neuroscience letters, 114(3), 259-264 (1990-07-13)
Quaternary derivatives of naloxone and other compounds are assumed not to enter the central nervous system following systemic administration. We report that i.p. naloxone methylbromide (5 mg/kg) completely reversed the antinociceptive effect of systemically administered morphine (6 mg/kg) in acutely
Inhibition of granulocyte ROS production by opioids prevents regeneration
Labit E, et al.
bioRxiv, 182584-182584 (2017)
Helvira Melo et al.
Scientific reports, 8(1), 15551-15551 (2018-10-21)
Opioids remain the gold standard for the treatment of moderate to severe pain. However, their analgesic properties come with important side effects, including pruritus, which occurs frequently after systemic or neuraxial administration. Although part of the opioid-induced itch is mediated
Delta opioid receptors are essential to the antiallodynic action of Β2-mimetics in a model of neuropathic pain.
Mélanie Kremer et al.
Molecular pain, 16, 1744806920912931-1744806920912931 (2020-03-27)
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