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Merck
CN

N145

Sigma-Aldrich

[Lys5, MeLeu9, Nle10]-α-Neurokinin Fragment 4-10

>98%

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关于此项目

经验公式(希尔记法):
C39H64N8O10
分子量:
804.97
MDL编号:
UNSPSC代码:
12352200
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方案

>98%

UniProt登记号

储存温度

−20°C

SMILES字符串

CCCC[C@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(O)=O

基因信息

human ... TAC1(6863)

Amino Acid Sequence

Asp-Lys-Phe-Val-Gly-(NMe-Leu)-Nle-NH

生化/生理作用

Potent NK-2 tachykinin receptor agonist.

法规信息

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分析证书(COA)

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J L Black et al.
British journal of pharmacology, 107(2), 429-436 (1992-10-01)
1. In many species, both NK1 and NK2 tachykinin receptors appear to be important in mediating the contraction of airway smooth muscle. We have examined the distribution and characterization of receptors for tachykinins in rabbit airways using functional length tension
L Fisher et al.
Regulatory peptides, 46(1-2), 396-398 (1993-07-02)
Tachykinin receptors mediating uterotonic effects were examined in preparations from oestrogen-primed rats. In the absence of peptidase inhibitors [Lys5-MeLeu9-Nle10] NKA (4-10) was 14-fold more potent than neurokinin A (NKA), but the two peptides were equipotent in the presence of phosphoramidon
G Chassaing et al.
Neuropeptides, 19(2), 91-95 (1991-06-01)
All the synthetized NKA and NKA (4-10) agonists have been found active in the rat portal vein bioassay. Even [Lys5, MeLeu9, Nle10] NKA(4-10), a highly potent competitor of NK-2 binding sites with very low binding potencies for NK-1 and NK-3

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