N151
Nisoxetine hydrochloride
≥98% (HPLC), Norepinephrine reuptake inhibitor, solid
别名:
(±)-γ-(2-Methoxyphenoxy)-N-methyl-benzenepropanamine hydrochloride, LY-94,939
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关于此项目
经验公式（希尔记法）:
C17H21NO2 · HCl
化学文摘社编号:
分子量:
307.82
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Nisoxetine hydrochloride, solid, ≥98% (HPLC)
SMILES string
Cl[H].CNCCC(Oc1ccccc1OC)c2ccccc2
InChI key
LCEURBZEQJZUPV-UHFFFAOYSA-N
InChI
1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
white to beige
solubility
H2O: 20 mg/mL
ethanol: 50 mg/mL
Quality Level
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Application
Nisoxetine has been used as a norepinephrine transport (NET) blocker in autoradiography studies. It has also been used as a NET blocker to study its effects on perivascular adipose tissue.
Biochem/physiol Actions
Nisoxetine is a selective and potent noradrenaline reuptake inhibitor. It has a high affinity towards the noradrenaline transporter. Nisoxetine possesses antidepressant activity.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Ching-I A Wang et al.
Molecular pharmacology, 82(5), 898-909 (2012-08-10)
The human norepinephrine transporter (NET) is implicated in many neurological disorders and is a target of tricyclic antidepressants and nisoxetine (NX). We used molecular docking simulations to guide the identification of residues likely to affect substrate transport and ligand interactions
B E Leonard
Neurochemistry international, 4(5), 339-350 (1982-01-01)
An attempt has been made to assess critically the clinical and experimental evidence that implicates a malfunctioning of amine neurotransmitter systems in the aetiology of depression. The evidence available does provide indirect evidence in favour of the biogenic amine theory
S M Tejani-Butt
The Journal of pharmacology and experimental therapeutics, 260(1), 427-436 (1992-01-01)
The uptake sites for norepinephrine (NE) in brain have not been studied in much detail, probably due to the absence of an adequate radioligand for labeling these sites. This study describes the binding properties of [3H]nisoxetine to uptake sites for
Dagmar E Ettlinger et al.
Nuclear medicine and biology, 35(4), 475-479 (2008-05-17)
Since the late 1980s, cocaine analogues based on the phenyltropane structure, such as [(11)C]CFT and [(123)I]beta-CIT have been used for the imaging of the dopamine transporter. FE@CIT (fluoropropyl ester) and FP-CIT (N-fluoropropyl derivative) are further analogues. The aim of this
Paola Devoto et al.
Frontiers in pharmacology, 11, 588160-588160 (2020-10-20)
Previous results indicate that dopamine (DA) release in the medial prefrontal cortex (mPFC) is modified by α2 adrenoceptor- but not D2 DA receptor- agonists and antagonists, suggesting that DA measured by microdialysis in the mPFC originates from noradrenergic terminals. Accordingly
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