N151
Nisoxetine hydrochloride
≥98% (HPLC), Norepinephrine reuptake inhibitor, solid
别名:
(±)-γ-(2-Methoxyphenoxy)-N-methyl-benzenepropanamine hydrochloride, LY-94,939
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关于此项目
经验公式（希尔记法）:
C17H21NO2 · HCl
化学文摘社编号:
分子量:
307.82
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
Nisoxetine hydrochloride, solid, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 20 mg/mL
ethanol: 50 mg/mL
SMILES字符串
Cl[H].CNCCC(Oc1ccccc1OC)c2ccccc2
InChI
1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H
InChI key
LCEURBZEQJZUPV-UHFFFAOYSA-N
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相关类别
应用
Nisoxetine has been used as a norepinephrine transport (NET) blocker in autoradiography studies. It has also been used as a NET blocker to study its effects on perivascular adipose tissue.
生化/生理作用
Nisoxetine is a selective and potent noradrenaline reuptake inhibitor. It has a high affinity towards the noradrenaline transporter. Nisoxetine possesses antidepressant activity.
特点和优势
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Jacob P R Jacobsen et al.
Psychopharmacology, 199(2), 137-150 (2008-05-23)
Exploring differences between mouse strains in drug effects in models of antidepressant-like activity may provide clues to the neurobiology of antidepressant responses. The objective of this study was to explore whether insensitivity to selective serotonin reuptake inhibitors (SSRIs) in NMRI
S M Tejani-Butt et al.
European journal of pharmacology, 191(2), 239-243 (1990-11-27)
[3H]Nisoxetine binds with high affinity (Kd = 0.7 nM) and selectivity to a homogenous population of sites associated with the uptake of norepinephrine. Specific [3H]nisoxetine binding to rat cortical homogenates was saturable, sodium-dependent and averaged 90% of total binding at
Adjmal Nahimi et al.
International review of neurobiology, 141, 251-274 (2018-10-14)
Noradrenergic neurons in both the peripheral nervous system and in the central nervous system (CNS) undergo severe degeneration in patients with Parkinson's disease (PD). This loss of noradrenaline may play essential roles in the occurrence of a wide range of
S C Cheetham et al.
Neuropharmacology, 35(1), 63-70 (1996-01-01)
Nisoxetine is a potent and selective inhibitor of noradrenaline uptake into noradrenergic neurones. [3H]Nisoxetine binding to rat frontal cortical membranes was of high affinity. The binding data of both competition and saturation studies fitted a single site binding model. [3H]Nisoxetine
Paola Devoto et al.
Frontiers in pharmacology, 11, 588160-588160 (2020-10-20)
Previous results indicate that dopamine (DA) release in the medial prefrontal cortex (mPFC) is modified by α2 adrenoceptor- but not D2 DA receptor- agonists and antagonists, suggesting that DA measured by microdialysis in the mPFC originates from noradrenergic terminals. Accordingly
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