N1780
Neurotrophin-4 human
recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture, >97% (SDS-PAGE)
别名:
NTF4, NT-4
生物来源
human
重组
expressed in baculovirus infected Sf21 cells
方案
>97% (SDS-PAGE)
表单
lyophilized powder
效能
0.3-15.0 ng/mL EC50
分子量
14 kDa
包装
pkg of 5 μg
技术
cell culture | mammalian: suitable
杂质
endotoxin, tested
UniProt登记号
储存温度
−20°C
基因信息
human ... NTF4(4909)
生化/生理作用
Neurotrophin-4 (also called NT-4/5 or NT-5) is a 14 kDa member of the neurotrophin family. NT-4 shares 95% sequence homology between human and rat. NT-4 from human, rat, and Xenopus are active on chick dorsal root ganglia. NT-4 is expressed in many tissues and major brain regions. NT-4 promotes survival and differentiation of various cells in culture including spinal neuons, basal forebrain cholinergic neurons, hippocampal neurons, cerebellar granule cells, embryonic dopaminergic neruons of mesencephalon, noradrenergic neurons of the locus coeruleus, dopaminergic, GABAergic, and serotoninergic neurons of the substantia nigra, and embryonic trigeminal and jugular neurons.
外形
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA, containing 50 μg bovine serum albumin per 1 μg of cytokine.
分析说明
The biological activity is measured in a cell proliferation assay using a TrkB-transfected cell line BaF-TrkB-BD.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
含少量动物源组分生物产品
常规特殊物品
此项目有
T Timmusk et al.
The European journal of neuroscience, 5(6), 605-613 (1993-06-01)
The neurotrophin gene family includes four structurally related proteins with neurotrophic activities. Two of them, nerve growth factor and brain-derived neurotrophic factor (BDNF), have been studied in detail and information has recently emerged on the expression and function of the
Daniel Todd et al.
PloS one, 9(2), e87923-e87923 (2014-02-08)
Huntington's disease (HD) is a devastating, genetic neurodegenerative disease caused by a tri-nucleotide expansion in exon 1 of the huntingtin gene. HD is clinically characterized by chorea, emotional and psychiatric disturbances and cognitive deficits with later symptoms including rigidity and
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