生物来源
mouse
偶联物
unconjugated
抗体形式
ascites fluid
抗体产品类型
primary antibodies
克隆
NFn27b, monoclonal
种属反应性
rat, mouse, human
技术
immunohistochemistry: suitable
microarray: suitable
western blot: 1:100-1:200 using rat brain cytosolic extract
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... NF1(4763)
mouse ... Nf1(18015)
rat ... Nf1(24592)
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一般描述
Neurofibromin 1 (NF1) is tumor suppressor. The gene encoding it is localized on human chromosome 17q11.2.
免疫原
synthetic peptide corresponding to amino acids 27-41 located in the N-terminus of human neurofibromin.
应用
Clone NFn27b is recommended over clone NFn27a (Product Code N 3537) for immunohistochemistry assays.
生化/生理作用
Neurofibromin 1 (NF1) acts as a negative regulator of RAS (a GTPase). Mutations in the gene encoding it have been associated with neurofibromatosis type 1 and melanoma.
外形
Ascites fluid with 15 mM sodium azide as a preservative.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
M Adelita Vizcaíno et al.
Human pathology, 46(9), 1323-1330 (2015-07-21)
Recent studies have identified somatic alterations in the gene encoding for neurofibromin (NF1) in a subset of glioblastoma (GBM), usually associated with the mesenchymal molecular subtype. To understand the significance of NF1 genetic alterations in diffuse gliomas in general, we
Meng-Chang Hsiao et al.
American journal of human genetics, 97(2), 238-249 (2015-07-21)
Genomic rearrangements can cause both Mendelian and complex disorders. Currently, several major mechanisms causing genomic rearrangements, such as non-allelic homologous recombination (NAHR), non-homologous end joining (NHEJ), fork stalling and template switching (FoSTeS), and microhomology-mediated break-induced replication (MMBIR), have been proposed.
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.
Michael Krauthammer et al.
Nature genetics, 47(9), 996-1002 (2015-07-28)
We report on whole-exome sequencing (WES) of 213 melanomas. Our analysis established NF1, encoding a negative regulator of RAS, as the third most frequently mutated gene in melanoma, after BRAF and NRAS. Inactivating NF1 mutations were present in 46% of
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