biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
NFn27b, monoclonal
species reactivity
rat, mouse, human
technique(s)
immunohistochemistry: suitable, microarray: suitable, western blot: 1:100-1:200 using rat brain cytosolic extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... NF1(4763)
mouse ... Nf1(18015)
rat ... Nf1(24592)
General description
Neurofibromin 1 (NF1) is tumor suppressor. The gene encoding it is localized on human chromosome 17q11.2.
Immunogen
synthetic peptide corresponding to amino acids 27-41 located in the N-terminus of human neurofibromin.
Application
Clone NFn27b is recommended over clone NFn27a (Product Code N 3537) for immunohistochemistry assays.
Biochem/physiol Actions
Neurofibromin 1 (NF1) acts as a negative regulator of RAS (a GTPase). Mutations in the gene encoding it have been associated with neurofibromatosis type 1 and melanoma.
Physical form
Ascites fluid with 15 mM sodium azide as a preservative.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
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Meng-Chang Hsiao et al.
American journal of human genetics, 97(2), 238-249 (2015-07-21)
Genomic rearrangements can cause both Mendelian and complex disorders. Currently, several major mechanisms causing genomic rearrangements, such as non-allelic homologous recombination (NAHR), non-homologous end joining (NHEJ), fork stalling and template switching (FoSTeS), and microhomology-mediated break-induced replication (MMBIR), have been proposed.
M Adelita Vizcaíno et al.
Human pathology, 46(9), 1323-1330 (2015-07-21)
Recent studies have identified somatic alterations in the gene encoding for neurofibromin (NF1) in a subset of glioblastoma (GBM), usually associated with the mesenchymal molecular subtype. To understand the significance of NF1 genetic alterations in diffuse gliomas in general, we
Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.
Michael Krauthammer et al.
Nature genetics, 47(9), 996-1002 (2015-07-28)
We report on whole-exome sequencing (WES) of 213 melanomas. Our analysis established NF1, encoding a negative regulator of RAS, as the third most frequently mutated gene in melanoma, after BRAF and NRAS. Inactivating NF1 mutations were present in 46% of
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