N3788
Anti-Nap1 (N-terminal) antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-NCK-associated protein 1, Anti-NCKAP1, Anti-p125Nap1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
10
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~125 kDa
species reactivity
rat, mouse, human
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1 mg/mL
technique(s)
western blot: 0.5-1 μg/mL using 3T3 cells lysate and HEK-293T cells expressing human Nap1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NCKAP1(10787)
mouse ... Nckap1(50884)
rat ... Nckap1(58823)
General description
Nap1 is also known as Nap125, Nck-associated protein 1, NCKAP1 or histone chaperone NAP1. It is an essential component of this signaling complex. This gene is located on human chromosome 2q32. It is an important apoptosis-related gene.
Nap1 (N-terminal) interacts with Nck and may be involved in the downstream signaling of Nck [RGD].
The gene encoding NCK associated protein 1 (NAP-1) is localized on human chromosome 2q32 and is expressed in neuronal cells.
Application
Anti-Nap1 (N-terminal) antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
NCK associated protein 1 (NAP-1) has been shown to be downregulated in Alzheimer′s disease.
Nck-associated protein 1 (NAP1/NCKAP1) along with Sra1 and ABI1 (Abl interactor 1) is involved in stabilizing WAVE2. Removal of Nap1 or Sra1 by RNAi abrogated the formation of lamellipodia induced by growth factor. Nap1 interacts directly with Abi1. It has been shown that Nap1 mediates the interaction of the Nap1-PIR121 complex to Abi1. Nap1 may participates in neuronal cell death in Alzheimer′s disease (AD).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival
Maddala R, et al.
Developmental Biology, 360(1), 30-43 (2011)
Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease.
Suzuki T
Genomics, 63(2), 246-254 (2000)
Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation
Steffen A, et al.
The Embo Journal, 23(4), 749-759 (2004)
A Yamamoto et al.
Gene, 271(2), 159-169 (2001-06-22)
We previously reported the isolation of a novel apoptosis-related gene, human Nap1 (HGMW-approved symbol NCKAP1), the expression of which was strongly down-regulated in sporadic Alzheimer's disease (AD). Human Nap1 proved to be an orthologue of rat Nap1 which binds to
Andrew B E Brooks et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(15), 3915-3920 (2017-03-30)
To establish infections, Salmonella injects virulence effectors that hijack the host actin cytoskeleton and phosphoinositide signaling to drive pathogen invasion. How effectors reprogram the cytoskeleton network remains unclear. By reconstituting the activities of the Salmonella effector SopE, we recapitulated Rho
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