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Merck
CN

N4007

N-Nitroso-N-methylbutylamine

别名:

Methylbutylnitrosamine

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关于此项目

经验公式(希尔记法):
C5H12N2O
化学文摘社编号:
分子量:
116.16
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352116
MDL number:
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InChI

1S/C5H12N2O/c1-3-4-5-7(2)6-8/h3-5H2,1-2H3

SMILES string

CCCCN(C)N=O

InChI key

PKTSCJXWLVREKX-UHFFFAOYSA-N

form

liquid

density

0.93 g/mL (lit.)

storage temp.

2-8°C

Quality Level

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Packaging

Bulk package

pictograms

Skull and crossbonesHealth hazard

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 3 Oral - Carc. 1B

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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B Ludeke et al.
IARC scientific publications, (105)(105), 286-293 (1991-01-01)
Aliphatic methylalkylnitrosamines with a chain length of three to six carbon atoms are powerful oesophageal carcinogens in rats and have been shown to methylate target organ DNA preferentially. This class of carcinogens is efficiently metabolized not only in the oesophageal
T Kawanishi et al.
Cancer letters, 20(2), 157-164 (1983-09-01)
The effect of phenobarbital (PB) and 3-methylcholanthrene (MC) pretreatment on dealkylations of N-nitrosodimethylamine (NDMA), N-nitrosomethylbutylamine (NMBuA) and N-nitrosomethylbenzylamine (NMBeA) was investigated in rat hepatic microsomes. PB increased the demethylation and the debutylation of NMBuA and the debenzylation of NMBeA. MC
E Suzuki et al.
Japanese journal of cancer research : Gann, 76(3), 184-191 (1985-03-01)
In order to compare the extents of metabolic alpha-hydroxylation of the two alkyl groups in unsymmetrical N-nitrosodialkylamines, N-nitroso-N-alkylbutylamines (alkyl = methyl, ethyl, propyl, butyl, and amyl) were incubated with liver microsomes prepared from phenobarbital- or polychlorinated biphenyl (PCB)-treated and untreated
W Lijinsky et al.
Carcinogenesis, 1(2), 157-160 (1980-02-01)
Nitrosomethyl-n-butylamine and its derivatives, labeled with deuterium in the methyl group or at the alpha position of the butyl group, were given to rats in drinking water at equimolar doses for approximately 20 weeks. Two concentrations were used, 16 mg/l
P P Roller et al.
IARC scientific publications, (41)(41), 199-208 (1982-01-01)
Electron-impact mass spectra of N-nitrosomethyl-n-butylamine, 5 of its specifically deuterated anologs and its methyl-n-hexyl and methyl-n-octyl homologs have been examined. Hydrogen abstraction by the nitrosamino moiety dominates the rearrangement ions, especially at low ionization energy. All compounds exhibited the (M-OH)+

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