N4148
S-亚硝基
≥97%, Creatine kinase inhibitor, powder
别名:
GSNO, SNOG
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关于此项目
经验公式（希尔记法）:
C10H16N4O7S
CAS Number:
分子量:
336.32
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.32
Product Name
S-亚硝基, ≥97%
质量水平
方案
≥97%
表单
powder
溶解性
water: soluble 19.60-20.40 mg/mL
储存温度
−20°C
SMILES字符串
N[C@@H](CCC(=O)N[C@@H](CSN=O)C(=O)NCC(O)=O)C(O)=O
InChI
1S/C10H16N4O7S/c11-5(10(19)20)1-2-7(15)13-6(4-22-14-21)9(18)12-3-8(16)17/h5-6H,1-4,11H2,(H,12,18)(H,13,15)(H,16,17)(H,19,20)/t5-,6-/m0/s1
InChI key
HYHSBSXUHZOYLX-WDSKDSINSA-N
一般描述
S-亚硝基谷胱甘肽（GSNO）是一种内源性氮氧化物，在肺和脑的细胞外液中高表达。
应用
S-亚硝基谷胱甘肽（GSNO）已用作：
- 作为反相色谱的标准品，与化学蒸汽发生和原子荧光检测器（RPC-CVGAFS）和反相色谱荧光（RPC-FD）相结合。
- 作为分光光度法和高效液相色谱（HPLC）测定的标准品。
生化/生理作用
S-亚硝基谷胱甘肽（GSNO）抑制兔骨骼肌中肌浆网结合肌酸激酶的活性，并最终减少肌浆网囊泡中 ATP 驱动的 Ca2+ 摄取。气道细胞中的 GSNO 使气道平滑肌松弛并增强气道纤毛运动。它还阻断气道上皮阿米洛利敏感的钠转运，同时刺激钙依赖性上皮细胞氯转运并诱导中性粒细胞凋亡。此外，它还具有抗菌活性。囊性纤维化（CF）气道中 GSNO 浓度低。它是NO供体，可作为平滑肌松弛剂和血管扩张剂，并且能抑制体内的血小板活化。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
C A Staab et al.
Cellular and molecular life sciences : CMLS, 65(24), 3950-3960 (2008-11-18)
Alcohol dehydrogenase 3 (ADH3) is highly conserved, ubiquitously expressed in mammals and involved in essential cellular pathways. A large active site pocket entails special substrate specificities: shortchain alcohols are poor substrates, while medium-chain alcohols and particularly the glutathione adducts S-hydroxymethylglutathione
Inhibition of creatine kinase by S-nitrosoglutathione.
Wolosker H
Febs Letters, 392(3), 274-276 (1996)
Benjamin Gaston et al.
American journal of respiratory and critical care medicine, 173(11), 1186-1193 (2006-03-11)
Genetic and biochemical data demonstrate a pivotal role for S-nitrosothiols (SNOs) in mediating the actions of nitric oxide synthases (NOSs). SNOs serve to convey NO bioactivity and to regulate protein function. This understanding is of immediate interest to the pulmonary
C C Chiueh et al.
Free radical research, 31(6), 641-650 (2000-01-12)
Recent results demonstrated that S-nitrosoglutathione (GSNO) and nitric oxide (*NO) protect brain dopamine neurons from hydroxyl radical (*OH)-induced oxidative stress in vivo because they are potent antioxidants. GSNO and *NO terminate oxidant stress in the brain by (i) inhibiting iron-stimulated
Roshan Kumar et al.
Scientific reports, 7, 44558-44558 (2017-03-17)
Ubiquitin C-terminal Hydrolase-1 (UCHL1) is a deubiquitinating enzyme, which plays a key role in Parkinson's disease (PD). It is one of the most important proteins, which constitute Lewy body in PD patient. However, how this well folded highly soluble protein
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