N5023
去甲二氢愈创木酸
≥90% (HPLC), from Larrea divaricata (creosote bush)
别名:
1,4-双(3,4-二羟苯基)-2,3-二甲基丁烷, 4,4′-(2,3-二甲基四亚甲基)二邻苯二酚, NDGA, 马索罗酚
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线性分子式:
[-CH(CH3)CH2C6H3-1,2-(OH)2]2
化学文摘社编号:
分子量:
302.36
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
EC Number:
207-903-0
Beilstein/REAXYS Number:
2056826
MDL number:
产品名称
去甲二氢愈创木酸, ≥90% (HPLC), from Larrea divaricata (creosote bush)
InChI key
HCZKYJDFEPMADG-UHFFFAOYSA-N
InChI
1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3
SMILES string
CC(Cc1ccc(O)c(O)c1)C(C)Cc2ccc(O)c(O)c2
biological source
Larrea divaricata (creosote bush)
assay
≥90% (HPLC)
form
crystalline
mp
184-186 °C (lit.)
solubility
ethanol: 50 mg/mL, clear to slightly hazy
Gene Information
human ... ALOX15(246), PTGS1(5742), PTGS2(5743)
mouse ... Alox12(11684)
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Biochem/physiol Actions
脂氧合酶抑制剂；含多酚的邻二羟基（儿茶酚）结构。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Ana I Rojo et al.
Free radical biology & medicine, 52(2), 473-487 (2011-12-07)
Defense against oxidative stress is executed by an antioxidant program that is tightly controlled by the transcription factor Nrf2. The stability of Nrf2 involves the interaction of two degradation domains, designated Neh2 and Neh6, with the E3 ubiquitin ligase adaptors
Lorena Palacio et al.
Plant science : an international journal of experimental plant biology, 193-194, 1-7 (2012-07-17)
The lignan nordihydroguaiaretic acid (NDGA) and its derivatives existing in Larrea divaricata species show a wide range of pharmacological activities which makes this genus an interesting target to consider the plant in vitro cultivation systems as a feasible alternative source
Irina Daurkin et al.
Cancer research, 71(20), 6400-6409 (2011-09-09)
Renal cell carcinoma (RCC), the most common human kidney cancer, is frequently infiltrated with tumor-associated macrophages (TAM) that can promote malignant progression. Here, we show that TAMs isolated from human RCC produce substantial amounts of the proinflammatory chemokine CCL2 and
Michael Scholz et al.
Bioorganic & medicinal chemistry, 17(2), 558-568 (2008-12-23)
Three series of non-steroidal anti-inflammatory drugs (NSAIDs) inhibiting the cyclooxygenase/5-lipoxygenase (COX/5-LOX) pathways as such as formation of hydroxyl radicals and adhesion were prepared: 4,5-diaryl isothiazoles, 4,5-diaryl 3H-1,2-dithiole-3-thiones and 4,5-diaryl 3H-1,2-dithiole-3-ones. The aim of the present study was to develop substances
Malcolm J Daniels et al.
Scientific reports, 9(1), 2937-2937 (2019-03-01)
Growing evidence implicates α-synuclein aggregation as a key driver of neurodegeneration in Parkinson's disease (PD) and other neurodegenerative disorders. Herein, the molecular and structural mechanisms of inhibiting α-synuclein aggregation by novel analogs of nordihydroguaiaretic acid (NDGA), a phenolic dibenzenediol lignan
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