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线性分子式:
O2N(CH2)2CO2H
化学文摘社编号:
分子量:
119.08
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
208-003-0
MDL number:
Beilstein/REAXYS Number:
1759889
产品名称
3-硝基丙酸, ≥97%
InChI key
WBLZUCOIBUDNBV-UHFFFAOYSA-N
InChI
1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)
SMILES string
OC(CC[N+]([O-])=O)=O
biological source
synthetic
assay
≥97%
form
powder or crystals
color
white to light yellow
mp
68-70 °C (lit.)
solubility
alcohol: may be light yellow 100 mg/mL
storage temp.
2-8°C
Quality Level
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Application
3-硝基丙酸已用于:
- 建立大鼠的多系统萎缩-帕金森症(MSA-P)模型,评估其对胚胎纹状体和中脑移植物的影响
- 注入大鼠的黑质纹状体多巴胺能通路,研究其对多巴胺系统的特定作用
- 作为LUHMES神经元和细胞系的琥珀酸脱氢酶(SDH)抑制剂
Biochem/physiol Actions
兴奋性神经毒素,证明可引起类似于 Huntington 疾病的脑损伤。
内耳施用3-硝基丙酸(3-NP)会导致感音神经性听力损失。它可作为线粒体复合体II的不可逆抑制剂。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
No functional effects of embryonic neuronal grafts on motor deficits in a 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy)
Waldner R, et al.
Neuroscience, 102(3), 581-592 (2001)
Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors
Lorendeau D, et al.
Metabolic engineering, 43, 187-197 (2017)
Specific lesions in the extrapyramidal system of the rat brain induced by 3-nitropropionic acid (3-NPA)
Pei G and Ebendal T
Experimental Neurology, 132(1), 105-115 (1995)
Mouse Models of Dystonia
Animal Models of Movement Disorders (2005)
The protective effect of Egb 761 against 3-nitropropionic acid-induced hearing loss: the role of sirtuin 1
Chang M Y, et al.
Clinical and Experimental Otorhinolaryngology, 11(1), 9-9 (2018)
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