产品名称
氯化镍(II) 六水合物, BioReagent, suitable for cell culture
InChI
1S/2ClH.Ni.6H2O/h2*1H;;6*1H2/q;;+2;;;;;;/p-2
SMILES string
[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].Cl[Ni]Cl
InChI key
LAIZPRYFQUWUBN-UHFFFAOYSA-L
product line
BioReagent
form
powder
technique(s)
cell culture | mammalian: suitable
Quality Level
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Application
六水氯化镍 (II):
- 用于制备镍镀层溶液,用于在合成多壁碳纳米管微电机过程中还原碳层内部对镍进行静电镀膜
- 用于筛选金属对血管内皮细胞的炎症效应
- 作为人工脑脊液(ACSF)的添加剂,用于分析海马脑片中兴奋性突触后电流(EPSPs)
Biochem/physiol Actions
镍 (Ni) 是人体必需的微量元素,对 DNA、RNA 和蛋白质的结构和功能均具有重要作用。其在较高浓度时对肾、肺及心血管系统有毒性作用。镍与致癌作用有关。Ni 2 + 离子是一种诱裂剂。镍离子 (Ni2 + ) 是一种非特异性电压门控钙通道阻滞剂。
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A Inhalation - Muta. 2 - Repr. 1B - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 1 Inhalation
target_organs
Lungs
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
危险化学品
此项目有
Nonrandom chromosomal alterations in nickel-transformed Chinese hamster embryo cells
Conway K and Costa M
Cancer Research, 49(21), 6032-6038 (1989)
Studies on the genotoxic effect of nickel chloride in mice and the possible protective role of soybean seeds extracts
Fahmy MA, et al.
Global Journal of Pharmacology, 8(4), 625-634 (2014)
Functional coupling of Cav2.3 and BK potassium channels regulates action potential repolarization and short-term plasticity in the mouse hippocampus
Gutzmann JJ, et al.
Frontiers in Cellular Neuroscience, 13(3), 492-499 (2019)
Effects of chemostimuli on [Ca2+] i responses of rat aortic body type I cells and endogenous local neurons: comparison with carotid body cells
Piskuric NA and Nurse CA
The Journal of Physiology, 590(9), 2121-2135 (2012)
Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium
Salnikow K and Zhitkovich A
Chemical Research in Toxicology, 21(1), 28-44 (2007)
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