N7009
2-硝基-5-氰硫基苯甲酸
≥98% (HPLC)
别名:
2-硝基-5-硫氰基苯甲酸, NTCB
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关于此项目
线性分子式:
O2NC6H3(SCN)CO2H
化学文摘社编号:
分子量:
224.19
Beilstein:
2124001
EC 号:
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26
产品名称
2-硝基-5-氰硫基苯甲酸, powder
方案
≥98% (HPLC)
质量水平
表单
powder
颜色
yellow
mp
156-157 °C (lit.)
储存温度
2-8°C
SMILES字符串
OC(=O)c1cc(SC#N)ccc1[N+]([O-])=O
InChI
1S/C8H4N2O4S/c9-4-15-5-1-2-7(10(13)14)6(3-5)8(11)12/h1-3H,(H,11,12)
InChI key
NQUNIMFHIWQQGJ-UHFFFAOYSA-N
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应用
- 利用2-硝基-5-硫氰酸进行蛋白质中的半胱氨酸至脱氢丙氨酸的位点特异性转化：该研究展示了如何在蛋白质工程中使用2-硝基-5-硫氰酸对半胱氨酸残基进行修饰，这对于开发治疗性蛋白质和理解蛋白质结构-功能关系至关重要（Qiao et al., 2021）。
- 通过有限蛋白水解和质谱法获得搔痒朊病毒蛋白结构约束：强调了2-硝基-5-硫氰酸对朊病毒蛋白研究的效用，为蛋白质错误折叠疾病提供了启示，有助于推出新的治疗方法（Sajnani et al., 2008）。
- 利用放射性亲和标记和半胱氨酸取代接近性方法将人还原性叶酸载体的底物结合域定位到跨膜结构域11：在生化分析中利用2-硝基-5-硫氰酸对转运蛋白的理解，这是药物传递和靶向所必需的（Hou et al., 2005）。
- 一种利用氰基化反应制备生物活性重组肽的新方法：介绍了一种利用2-硝基-5-硫氰酸对多肽进行合成的方法，有利于多肽类药物的开发（Koyama et al., 1994）。
生化/生理作用
2-硝基-5-氰硫基苯甲酸（NTCB）常用于在半胱氨酸残基处氰化和切割蛋白质。
包装
无底玻璃瓶。内含物在插入的融合锥体内。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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In addition to its kinase activity, myosin light chain kinase has an actin-binding activity, which results in bundling of actin filaments [Hayakawa et al., Biochem. Biophys. Res. Commun. 199, 786-791, 1994]. There are two actin-binding sites on the kinase: calcium-
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