N7878
呋喃妥因
98.0-102.0% (EP, UV)
别名:
N -（5-硝基-2-呋喃亚基）-1-氨基乙内酰脲, 呋喃坦啶, 硝基呋喃妥因
质量水平
方案
98.0-102.0% (EP, UV)
表单
(Crystalline Powder or crystals)
颜色
yellow
溶解性
DMF: soluble 50 mg/mL
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
DNA synthesis | interferes
cell wall synthesis | interferes
protein synthesis | interferes
SMILES字符串
[O-][N+](=O)c1ccc(\C=N\N2CC(=O)NC2=O)o1
InChI
1S/C8H6N4O5/c13-6-4-11(8(14)10-6)9-3-5-1-2-7(17-5)12(15)16/h1-3H,4H2,(H,10,13,14)/b9-3+
InChI key
NXFQHRVNIOXGAQ-YCRREMRBSA-N
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应用
呋喃妥因是一种硝基呋喃类抗生素，用作细菌硝基呋喃还原酶的底物，研究活性代谢物与 DNA、核糖体蛋白以及代谢和促氧化过程的相互作用。用于研究呋喃妥因引起的毒性 及抗生素耐药性 。呋喃妥因适合于体外杀灭单核细胞增生性李斯特菌。研究描述了使用抗氧化剂减轻呋喃妥因对培养人 WI-38 成纤维细胞的毒性作用。据报道，包括呋喃妥因在内的各种抗生素可引起离体牛乳腺多形核白细胞体外形态特征、活力和吞噬活性的改变。
生化/生理作用
呋喃妥因是一种抗菌化合物，历史上一直通过 1-氨基乙内酰硫酸酯与 5-硝基-2-呋喃甲醛二乙酸酯反应制备。对许多革兰阳性菌和革兰阴性菌有抗菌活性。呋喃妥因对肠球菌、葡萄球菌、链球菌、角质菌、许多大肠埃希氏菌 菌株和 变形杆菌属的大多数菌株有效 。且 假单胞菌绿脓杆菌 对该化合物的抗性更强。呋喃妥因被细菌黄素蛋白（硝基呋喃还原酶）激活，主动还原调节和损伤核糖体蛋白或其他大分子（如 DNA）的活性中间体。这抑制了导致细胞死亡的 DNA、RNA、蛋白质和细胞壁合成 。呋喃妥因具有较低的耐药潜力，可被哺乳动物迅速代谢，对革兰阳性菌和革兰阴性菌均有活性。它也是一种促氧化剂，由于产生细胞内 H2O2 而具有细胞毒性。为谷胱甘肽还原酶抑制剂。呋喃妥因通过硝基及其自由基阴离子的氧化还原循环产生肝毒性，导致氧化应激。
其他说明
将容器密闭保存在干燥和通风良好的地方。对光敏感。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
J Pourahmad et al.
Advances in experimental medicine and biology, 500, 261-265 (2002-01-05)
1. The enzymes responsible for the reductive activation of NFT are not known. We have now shown that under aerobic conditions, inhibitors of cytochrome P450 or P450 reductase but not DT diaphorase prevented NFT induced cytotoxicity and reactive oxygen species
W Shen et al.
Human & experimental toxicology, 15(5), 428-434 (1996-05-01)
1. Nitrofurantoin is an antimicrobial agent which produces hepatotoxicity caused by the redox cycling of the nitro group and its radical anion. This futile cycling triggers a complex series of events known collectively as oxidative stress. 2. Our goal was
S C Nickerson et al.
American journal of veterinary research, 46(11), 2259-2265 (1985-11-01)
Effects of antibiotics and antibiotic vehicles on polymorphonuclear leukocytes (PMNL) isolated from bovine mammary glands were studied in vitro. Amikacin, dicloxacillin, erythromycin, gentamicin, lincomycin, nitrofurantoin, novobiocin-penicillin, polymyxin B, rifampin, tetracycline, or tiamulin was added to culture medium at 1 mg/ml
C Michiels et al.
Biochimica et biophysica acta, 967(3), 341-347 (1988-12-15)
The toxicity of nitrofurantoin was studied on human WI-38 fibroblasts: this chemical was lethal when added at concentrations higher than 5.10(-5) M in the culture medium. The protection afforded by antioxidants was then tested: alpha-tocopherol gave at 10(-4) M a
Martindale: The Extra Pharmacopoeia
Martindale: The Extra Pharmacopoeia, 1529-1531 (1996)
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