N8010
4-Nitrophenyl 4-guanidinobenzoate hydrochloride
protease substrate, ≥95.0% (TLC), powder
别名:
4-Guanidinobenzoic acid 4-nitrophenylester hydrochloride, NPGB, pNPGB
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关于此项目
经验公式（希尔记法）:
C14H12N4O4 · HCl
CAS Number:
分子量:
336.73
Beilstein:
8024554
EC 号:
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.32
Product Name
4-Nitrophenyl 4-guanidinobenzoate hydrochloride, protease inhibitor and substrate
质量水平
方案
≥95.0% (TLC)
表单
powder
溶解性
formic acid: soluble 49.00-51.00 mg/mL
储存温度
−20°C
SMILES字符串
Cl[H].NC(=N)Nc1ccc(cc1)C(=O)Oc2ccc(cc2)[N+]([O-])=O
InChI
1S/C14H12N4O4.ClH/c15-14(16)17-10-3-1-9(2-4-10)13(19)22-12-7-5-11(6-8-12)18(20)21;/h1-8H,(H4,15,16,17);1H
InChI key
PKSBDZOBYIKNGY-UHFFFAOYSA-N
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一般描述
4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) is a trypsin substrate. It is more water-soluble than 4-methylumbelliferyl 4-guanidinobenzoate and is preferred in spectrophotometric assay.
应用
4-Nitrophenyl 4-guanidinobenzoate hydrochloride has been used:
- as a substrate for trypsin for active site titration experiments
- for pre-treating of mosquito eggs in the interplasmid transposition assay
- as a component of isotonic buffer to moisten filter paper for mosquito embryo collection
生化/生理作用
4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) inhibits phenoloxidase enzyme and delays embryo chorionic membrane hardening.
警示用语：
Danger
危险声明
危险分类
Eye Dam. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
R N Pittman et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 9(12), 4269-4286 (1989-12-01)
Sympathetic neurons release both urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA). A number of inhibitors of serine proteases have been tested to determine their effects on neurite outgrowth from rat sympathetic neurons. Some inhibitors increase neurite outgrowth while
F Catteruccia et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(5), 2157-2162 (2000-02-19)
The ability of the Minos transposable element to function as a transformation vector in anopheline mosquitoes was assessed. Two recently established Anopheles gambiae cell lines were stably transformed by using marked Minos transposons in the presence of a helper plasmid
Qiuxiang Pang et al.
Fish & shellfish immunology, 17(5), 477-487 (2004-08-18)
The presence of phenoloxidase (PO) activity in the humoral fluid of amphioxus Branchiostoma belcheri tsingtauense was electrophoretically and spectrophotometrically studied. The enzyme was present in the humoral fluid predominantly as an inactive proenzyme, prophenoloxidase (proPO). The optimum temperature for activation
Agnieszka Jendroszek et al.
Thrombosis and haemostasis, 117(9), 1688-1699 (2017-08-05)
Plasminogen activator inhibitor type 1 (PAI-1) is a central regulator of fibrinolysis and tissue remodelling. PAI-1 belongs to the serpin superfamily and unlike other inhibitory serpins undergoes a spontaneous inactivation process under physiological conditions, termed latency transition. During latency transition
M Llanos et al.
Journal of reproduction and fertility, 97(1), 173-178 (1993-01-01)
In this study we evaluated the effect of several trypsin inhibitors (p-aminobenzamidine: pAB; N-alpha-p-tosyl-L-lysine-chloromethyl-ketone: TLCK and p-nitrophenyl-p'-guanidino-benzoate: NPGM) on sperm binding and penetration of the human zona pellucida. Motile spermatozoa, selected by a two-step Percoll gradient, were incubated at 1
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