Nilutamide

Name: Nilutamide
Brand: SIGMA

solid

别名:

5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione, Anandron, RU-23908

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₁₂H₁₀F₃N₃O₄

CAS Number:

63612-50-0

分子量:

317.22

MDL编号:

MFCD00864670

UNSPSC代码:

51111800

PubChem化学物质编号:

24278596

NACRES:

NA.77

表单

solid

质量水平

200

创始人

Sanofi Aventis

SMILES字符串

CC1(C)NC(=O)N(c2ccc(c(c2)C(F)(F)F)[N+]([O-])=O)C1=O

InChI

1S/C12H10F3N3O4/c1-11(2)9(19)17(10(20)16-11)6-3-4-8(18(21)22)7(5-6)12(13,14)15/h3-5H,1-2H3,(H,16,20)

InChI key

XWXYUMMDTVBTOU-UHFFFAOYSA-N

基因信息

human ... AR(367)

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应用

Nilutamide has been used:

as a nuclear androgen receptor (nAR) inhibitor to study its effects on oocyte maturation in zebrafish
to determine its effects on bioluminescent Saccharomyces cerevisiae bioreporters in BLYAS assay
as a substrate in hydrogenation reaction

生化/生理作用

Nilutamide is a nuclear androgen receptor inhibitor. It is a nonsteroidal antiandrogen that competitively inhibits the binding of dihydrotestosterone to the androgen receptor. Nilutamide shows a therapeutic effect against prostate cancer.

特点和优势

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.