O2136
油酸酰胺
≥99% (TLC), powder, sleep-inducing brain lipid
别名:
顺式-9,10-十八碳烯酰胺, 顺式-9-十八烯胺, 油酸酰胺
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关于此项目
经验公式（希尔记法）:
C18H35NO
化学文摘社编号:
分子量:
281.48
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
油酸酰胺, ≥99%
质量水平
方案
≥99%
药品控制
regulated under CDSA - not available from Sigma-Aldrich Canada
储存温度
−20°C
SMILES字符串
CCCCCCCC\C=C/CCCCCCCC(N)=O
InChI
1S/C18H35NO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H2,19,20)/b10-9-
InChI key
FATBGEAMYMYZAF-KTKRTIGZSA-N
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相关类别
一般描述
油酰胺是脂质或大脑脂肪酸，可在CSF（脑脊液）中找到。最初得自剥夺睡眠的猫的脑脊液。
应用
油酰胺已用作葡萄糖和半乳糖培养基中的补充剂，用于防止半乳糖诱导Leigh综合征。
生化/生理作用
油酰胺有促进睡眠的效果。它拥有多种属性，如大麻素类活性。油酰胺也可通过大鼠神经胶质细胞间隙连接阻断通信。
睡眠诱导脑脂质，其变构调节GABAA受体并增强5-HT7血清素受体反应。大鼠和人类CB1大麻素受体的选择性内源性激动剂。
危险声明
预防措施声明
危险分类
Aquatic Chronic 4
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
404.6 °F - closed cup
闪点(°C)
207 °C - closed cup
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Oleamide and anandamide effects on food intake and sexual behavior of rats
Martinez-Gonzalez D, et al.
Neuroscience Letters, 364(1), 1-6 (2004)
The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells
Guan X, et al.
The Journal of Cell Biology, 139(7), 1785-1792 (1997)
Varadarajan Sudhahar et al.
European journal of pharmacology, 607(1-3), 143-150 (2009-03-28)
Fatty acid amides are a new class of signaling lipids that have been implicated in diverse physiological and pathological conditions. Oleamide is a fatty acid amide that induces vasorelaxation. Here, we investigated the mechanisms behind the vasorelaxation effect of oleamide
Gayong Shim et al.
Journal of controlled release : official journal of the Controlled Release Society, 155(1), 60-66 (2010-10-26)
Oligolysine-based cationic lipid derivatives were synthesized for delivery of siRNA, and formulated into cationic liposomes. Among various oligolysine-based lipid derivatives differing in lysine residue number and lipid moiety, trilysinoyl oleylamide (TLO)-based liposomes (TLOL) showed the highest delivery efficiency combined with
Mónica Méndez-Díaz et al.
Addiction biology, 17(4), 725-735 (2010-12-25)
Endocannabinoids (eCBs) are mediators of the homeostatic and hedonic systems that modulate food ingestion. Hence, eCBs, by regulating the hedonic system, may be modulating the valence of the emotion associated to food ingestion (positive: pleasant or negative: unpleasant). Our first
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