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Merck
CN

O4511

豆渣酸 来源于凹形原甲藻

≥90% (HPLC), translucent film

别名:

OA

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关于此项目

经验公式（希尔记法）:
C44H68O13
化学文摘社编号:
78111-17-8
分子量:
805.00
UNSPSC Code:
12352202
PubChem Substance ID:
24897998
MDL number:
MFCD00083455

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storage temp.

−20°C

InChI

1S/C44H68O13/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49)/b10-9+/t26-,27-,28+,30+,31+,32+,33-,34+,35-,36-,37+,38+,39-,41-,42+,43-,44-/m1/s1

SMILES string

O[C@@H](C[C@@H]([C@@]1([H])O[C@@]2(CCCCO2)CC[C@H]1C)C)[C@]3([H])C([C@@H](O)[C@]4([H])O[C@]5(CC[C@@](/C=C/[C@@H](C)[C@@]6([H])O[C@]7(O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]7O)C=C(C)C6)([H])O5)CC[C@@]4([H])O3)=C

InChI key

QNDVLZJODHBUFM-WFXQOWMNSA-N

biological source

plant (Prorocentrum concavum)

assay

≥90% (HPLC)

form

translucent film

solubility

DMSO: ≥1 mg/mL, ethanol: ≥1 mg/mL, methanol: ≥1 mg/mL, H2O: insoluble

Biochem/physiol Actions

冈田酸是一种鞭毛藻毒素和38碳脂肪酸的离子载体样聚醚衍生物。
鞭毛藻毒素和 38 碳脂肪酸的类似离子载体样聚醚衍生物。容易进入细胞。1 型和 2A 型蛋白磷酸酶抑制剂。不抑制酪氨酸磷酸酶、碱性磷酸酶或酸性磷酸酶。已知的肿瘤促进剂。用于研究各种细胞过程，包括细胞周期、细胞凋亡、一氧化氮代谢和钙信号传导等。

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBK5786V
SLBK4954V
SLBK6729V
MKBR2410V
MKBQ8271V

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M Mourtada-Maarabouni et al.
Oncogene, 28(2), 195-208 (2008-10-07)
Effective control of both cell survival and cell proliferation is critical to the prevention of oncogenesis and to successful cancer therapy. Using functional expression cloning, we have identified GAS5 (growth arrest-specific transcript 5) as critical to the control of mammalian
Keiichi Konoki et al.
Bioorganic & medicinal chemistry, 18(21), 7607-7610 (2010-09-25)
Okadaic acid (OA) and dinophysistoxin-1 (DTX1) cause diarrheic shellfish poisoning. This article examines the biochemical interactions of the two toxins with novel okadaic acid binding proteins (OABPs) 2.1 and 2.3, originally isolated from the marine sponge Halichondria okadai. First, recombinant
M A Battistone et al.
Molecular human reproduction, 19(9), 570-580 (2013-05-01)
In all mammalian species studied so far, sperm capacitation correlates with an increase in protein tyrosine (Tyr) phosphorylation mediated by a bicarbonate-dependent cAMP/protein kinase A (PKA) pathway. Recent studies in mice revealed, however, that a Src family kinase (SFK)-induced inactivation
Sherzad K Rashid et al.
PloS one, 9(5), e97458-e97458 (2014-05-17)
Portal hypertension characterized by generalized vasodilatation with endothelial dysfunction affecting nitric oxide (NO) and endothelium-dependent hyperpolarization (EDH) has been suggested to involve bacterial translocation and/or the angiotensin system. The possibility that ingestion of probiotics prevents endothelial dysfunction in rats following
Rodrigo González-Romero et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 155(2), 175-181 (2011-09-29)
Marine biotoxins synthesized by Harmful Algal Blooms (HABs) represent one of the most important sources of contamination in marine environments as well as a serious threat to fisheries and aquaculture-based industries in coastal areas. Among these biotoxins Okadaic Acid (OA)
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Product Information Sheet - O4511

Product Information Sheet

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