P0028
PSN-375963
≥98% (HPLC)
别名:
4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine
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关于此项目
经验公式（希尔记法）:
C17H23N3O
化学文摘社编号:
分子量:
285.38
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98% (HPLC)
表单
powder
颜色
white to off-white
溶解性
DMSO: >10 mg/mL
储存温度
−20°C
SMILES字符串
CCCCC1CCC(CC1)c2nc(no2)-c3ccncc3
InChI
1S/C17H23N3O/c1-2-3-4-13-5-7-15(8-6-13)17-19-16(20-21-17)14-9-11-18-12-10-14/h9-13,15H,2-8H2,1H3
InChI key
OAVLEYPTWABFLF-UHFFFAOYSA-N
生化/生理作用
PSN-375963 is a GPR119 partial agonist.
PSN-375963 is a GPR119 partial agonist. GPR119 is an orphan GPCR, expressed predominantly in pancreas and GI tract, that has been characterized. Its endogenous ligands are oleoylethanolamide (OEA) and oleoyl-lysophosphatidylcholine, lipid signaling molecules that regulate food intake and body weight. OEA decreases food intake, so GPR119 agonists are potential therapies for obesity. Initial studies showed that PSN-375963 has similar potency and partial efficacy compared to OEA. Further studies revealed that although OEA and PSN-375963 are GPR119 agonists, they have divergent effects on insulin secretion, calcium signaling, and cAMP production.
储存分类代码
11 - Combustible Solids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Madusha Peiris et al.
Nutrients, 10(10) (2018-10-20)
Nutrient-sensing receptors located on enteroendocrine (EEC) cells modulate appetite via detection of luminal contents. Colonic 'tasting' of luminal contents may influence changes to appetite observed in obesity and after weight loss induced by bariatric surgery. We assessed the effects of
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