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Merck
CN

P0053

Sigma-Aldrich

PGLa

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关于此项目

经验公式（希尔记法）:
C88H162N26O22S
化学文摘社编号:
102068-15-5
分子量:
1968.45
UNSPSC代码:
51102829
NACRES:
NA.85

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表单

solid

质量水平

200

溶解性

H2O: 1 mg/mL

抗生素抗菌谱

Gram-negative bacteria
fungi
viruses

作用机制

cell membrane | interferes

储存温度

2-8°C

InChI

1S/C88H162N26O22S/c1-19-48(9)69(113-78(126)52(13)97-66(117)42-95-72(120)50(11)98-79(127)59(31-23-27-36-91)108-85(133)64(44-115)111-77(125)54(15)100-81(129)61(33-38-137-18)104-65(116)41-93)87(135)101-51(12)73(121)96-43-67(118)105-57(29-21-25-34-89)82(130)114-70(49(10)20-2)88(136)103-55(16)74(122)106-60(32-24-28-37-92)83(131)112-68(47(7)8)86(134)102-56(17)76(124)110-63(40-46(5)6)84(132)107-58(30-22-26-35-90)80(128)99-53(14)75(123)109-62(71(94)119)39-45(3)4/h45-64,68-70,115H,19-44,89-93H2,1-18H3,(H2,94,119)(H,95,120)(H,96,121)(H,97,117)(H,98,127)(H,99,128)(H,100,129)(H,101,135)(H,102,134)(H,103,136)(H,104,116)(H,105,118)(H,106,122)(H,107,132)(H,108,133)(H,109,123)(H,110,124)(H,111,125)(H,112,131)(H,113,126)(H,114,130)/t48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,68-,69-,70-/m0/s1

InChI key

PJRSUKFWFKUDTH-JWDJOUOUSA-N

Amino Acid Sequence

Gly-Met-Ala-Ser-Lys-Ala-Gly-Ala-Ile-Ala-Gly-Lys-Ile-Ala-Lys-Val-Ala-Leu-Lys-Ala-Leu-NH2

一般描述

化学结构：肽

应用

PGLa是一种阳离子抗菌肽(AMP)，最初从青蛙中分离得到。它已经被证明有抗菌，1 抗真菌，2和抗病毒，3 活性。 它被用来研究新的肽片段，来自PGLa和非洲爪蟾多核胃粘膜细胞。

生化/生理作用

PGLa的前体是蛙皮素和爪蟾肽。 PGLa对革兰氏阴性细菌的作用机制是破坏细胞脂质双层膜。4 它可用于诱导脂双层和细菌细胞膜中的跨膜孔形成。 它与蛙皮素2结合使用可产生协同效应。

其他说明

500ug
保存于密闭容器内，置于干燥通风处。

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
SLBQ7151V
SLBN9420V
SLBN5121V
SLBD6810V
SLBC8846V

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Karl Lohner et al.
Biochimica et biophysica acta, 1788(8), 1656-1666 (2009-06-02)
Peptidyl-glycine-leucine-carboxyamide (PGLa), isolated from granular skin glands of Xenopus laevis, is practically devoid of secondary structure in aqueous solution and in the presence of zwitterionic phospholipids, when added exogenously, but adopts an alpha-helix in the presence of anionic lipids. The
Marco Ieronimo et al.
Journal of the American Chemical Society, 132(26), 8822-8824 (2010-06-17)
(19)F NMR is a unique tool to examine the structure of fluorine-labeled peptides in their native cellular environment, due to an exquisite sensitivity and lack of natural abundance background. For solid-state NMR analysis, we isolated native membranes from erythrocyte ghosts
Mareike Hartmann et al.
Antimicrobial agents and chemotherapy, 54(8), 3132-3142 (2010-06-10)
Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to examine the ultrastructural changes in bacteria induced by antimicrobial peptides (AMPs). Both the beta-stranded gramicidin S and the alpha-helical peptidyl-glycylleucine-carboxyamide (PGLa) are cationic amphiphilic AMPs known to interact
Sameer A Ansari et al.
Journal of neurointerventional surgery, 3(4), 324-330 (2011-10-13)
Bioactive polyglycolic/polylactic acid (PGLA)-coated Matrix detachable coils were reported to incite intra-aneurysmal inflammation and fibrosis. Multiple large case series with Matrix-1 coils have shown no advantage with respect to aneurysm recurrence. Second-generation Matrix-2 coils were designed with improved platinum support
Theodore Parker et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 100(3), 603-610 (2012-01-31)
Sustained release formulations of a potent antithrombotic drug, cilostazol, in poly-(lactic acid-co-glycolic acid) (PLGA) matrices were created for luminal release from a novel drug-eluting stent utilizing reservoirs (RES TECHNOLOGY™). The crystallinity of cilostazol and the morphology of the cilostazol/polymer matrix
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