P0122
Pifithrin-μ
≥97% (HPLC), solid
别名:
2-苯乙炔磺胺, PFTμ
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关于此项目
经验公式（希尔记法）:
C8H7NO2S
化学文摘社编号:
分子量:
181.21
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥97% (HPLC)
表单
solid
储存条件
desiccated
溶解性
DMSO: soluble >10 mg/mL, clear
H2O: insoluble
储存温度
2-8°C
SMILES字符串
NS(=O)(=O)C#Cc1ccccc1
InChI
1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
InChI key
ZZUZYEMRHCMVTB-UHFFFAOYSA-N
相关类别
应用
菲丝菌素-μ 已用于:
- 处理小胶质细胞系以分析其对M1样和M2样表型的神经保护作用
- 作为热休克蛋白（HSP）-70抑制剂用于处理转染的Marc-145细胞
- 抑制热休克相关蛋白70（heat shock cognate，Hsc70）以阐明小鼠胚胎干细胞的热休克伴侣蛋白
生化/生理作用
Pifithrin- μ是p53结合和抗凋亡的抑制剂，其可直接抑制p53与线粒体以及Bcl-xL和Bcl-2蛋白的结合。
Pifithrin- μ是p53结合和抗凋亡的抑制剂，其可直接抑制p53与线粒体以及Bcl-xL和Bcl-2蛋白的结合。PFT μ可从致死γ -辐射诱导的细胞死亡中解救细胞。由于pifithrin- μ仅关闭p53-线粒体途径而不影响p53的转录功能，所以它比pifithrin-α 具有更优的性能。
在缺氧缺血（HI）诱发的新生儿脑病的临床前模型中，菲丝菌素μ（PFT-μ）具有防止细胞死亡的神经保护能力。它通过抑制分子伴侣热休克蛋白（HSP）-70与其底物的相互作用来抑制核因子ΙB（NF-ΙB）通路。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Tomohisa Horibe et al.
Molecular cancer, 11, 59-59 (2012-08-24)
Heat-shock protein 90 (Hsp90) is vital to cell survival under conditions of stress, and binds client proteins to assist in protein stabilization, translocation of polypeptides across cell membranes, and recovery of proteins from aggregates. Therefore, Hsp90 has emerged as an
Determination of the interactome of non-structural protein12 from highly pathogenic porcine reproductive and respiratory syndrome virus with host cellular proteins using high throughput proteomics and identification of HSP70 as a cellular factor for virus replication
Dong S, et al.
Journal of Proteomics, 146, 58-69 (2016)
The anti-inflammatory effects of the small molecule pifithrin-mu on BV2 microglia
Fleiss B, et al.
Developmental Neuroscience, 37(4-5), 363-375 (2015)
Tomoya Uchimura et al.
Frontiers in endocrinology, 10, 529-529 (2019-08-21)
Medaka (Oryzias latipes) are teleost fish with a XX/XY sex determination system. Recently, it was reported that high temperature (HT) induced the masculinization of XX medaka by increasing the levels of cortisol, a major glucocorticoid produced by interrenal cells in
Femke M Feringa et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 43(3), 347-358 (2022-12-15)
The presynaptic proteins MUNC18-1, syntaxin-1, and SNAP25 drive SNARE-mediated synaptic vesicle fusion and are also required for neuronal viability. Their absence triggers rapid, cell-autonomous, neuron-specific degeneration, unrelated to synaptic vesicle deficits. The underlying cell death pathways remain poorly understood. Here
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