P0122
Pifithrin-μ
≥97% (HPLC), solid
别名:
2-苯乙炔磺胺, PFTμ
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关于此项目
经验公式（希尔记法）:
C8H7NO2S
化学文摘社编号:
分子量:
181.21
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C8H7NO2S/c9-12(10,11)7-6-8-4-2-1-3-5-8/h1-5H,(H2,9,10,11)
SMILES string
NS(=O)(=O)C#Cc1ccccc1
InChI key
ZZUZYEMRHCMVTB-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
solid
storage condition
desiccated
solubility
DMSO: soluble >10 mg/mL, clear, H2O: insoluble
storage temp.
2-8°C
Quality Level
相关类别
Application
菲丝菌素-μ 已用于:
- 处理小胶质细胞系以分析其对M1样和M2样表型的神经保护作用
- 作为热休克蛋白（HSP）-70抑制剂用于处理转染的Marc-145细胞
- 抑制热休克相关蛋白70（heat shock cognate，Hsc70）以阐明小鼠胚胎干细胞的热休克伴侣蛋白
Biochem/physiol Actions
Pifithrin- μ是p53结合和抗凋亡的抑制剂，其可直接抑制p53与线粒体以及Bcl-xL和Bcl-2蛋白的结合。
Pifithrin- μ是p53结合和抗凋亡的抑制剂，其可直接抑制p53与线粒体以及Bcl-xL和Bcl-2蛋白的结合。PFT μ可从致死γ -辐射诱导的细胞死亡中解救细胞。由于pifithrin- μ仅关闭p53-线粒体途径而不影响p53的转录功能，所以它比pifithrin-α 具有更优的性能。
在缺氧缺血（HI）诱发的新生儿脑病的临床前模型中，菲丝菌素μ（PFT-μ）具有防止细胞死亡的神经保护能力。它通过抑制分子伴侣热休克蛋白（HSP）-70与其底物的相互作用来抑制核因子ΙB（NF-ΙB）通路。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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