主要文件

查看所有文档

P0543

5-Pregnen-3β-ol-20-one-16α-carbonitrile

Name: 5-Pregnen-3&#946;-ol-20-one-16&#945;-carbonitrile
Brand: SIGMA

synthetic (organic), ≥97%, glucocorticoid receptor antagonist, powder, crystals or chunks

别名:

Pregnenolone-16α-carbonitrile

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₂₂H₃₁NO₂

化学文摘社编号:

1434-54-4

分子量:

341.49

UNSPSC Code:

51111800

PubChem Substance ID:

24898113

NACRES:

NA.77

MDL number:

MFCD00272045

Assay:

≥97%

Form:

powder, crystals or chunks

Quality level:

100

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

产品名称

5-Pregnen-3β-ol-20-one-16α-carbonitrile, ≥97%

biological source

synthetic (organic)

Quality Level

100

sterility

non-sterile

assay

≥97%

form

powder, crystals or chunks

technique(s)

cell culture | mammalian: suitable

solubility

chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow (with heat)

shipped in

ambient

storage temp.

2-8°C

SMILES string

C[C@@]12[C@](C[C@@H](C#N)[C@@H]2C(C)=O)([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC1

InChI

1S/C22H31NO2/c1-13(24)20-14(12-23)10-19-17-5-4-15-11-16(25)6-8-21(15,2)18(17)7-9-22(19,20)3/h4,14,16-20,25H,5-11H2,1-3H3/t14-,16-,17+,18-,19-,20-,21-,22-/m0/s1

InChI key

VSBHRRMYCDQLJF-ZDNYCOCVSA-N

Application

5-Pregnen-3β-ol-20-one-16α-carbonitrile has been used:

in the induction of cytochrome P450
as pregnane X receptor (PXR) activator in human liver cell lines.

Biochem/physiol Actions

Pregnenolone-16a-carbonitrile (PCN) is a glucocorticoid receptor antagonist and a PXR (pregnane X receptor) activator.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

>199.9 °F - closed cup

flash_point_c

> 93.3 °C - closed cup

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Effect of lipopolysaccharide on the xenobiotic-induced expression and activity of hepatic cytochrome P450 in mice.

Nozomu Moriya et al.

Biological & pharmaceutical bulletin, 35(4), 473-480 (2012-04-03)

Infection-associated inflammation can alter the expression levels and functions of cytochrome P450s (CYPs). Cyp gene expression is regulated by the activation of several nuclear receptors, including pregnane X receptor (PXR), constitutive androstane receptor (CAR), and aryl hydrocarbon receptor (AhR). These

Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in zebrafish (Danio rerio).

Afonso C D Bainy et al.

Aquatic toxicology (Amsterdam, Netherlands), 142-143, 447-457 (2013-10-15)

The pregnane X receptor (PXR) (nuclear receptor NR1I2) is a ligand activated transcription factor, mediating responses to diverse xenobiotic and endogenous chemicals. The properties of PXR in fish are not fully understood. Here we report on cloning and characterization of

Gene expression profiling of drug metabolism and toxicology markers using a low-density DNA microarray

de Longueville F, et al.

Biochemical Pharmacology, 64(1), 137-149 (2002)

Activation of pregnane X receptor by pregnenolone 16 α-carbonitrile prevents high-fat diet-induced obesity in AKR/J mice.

Yongjie Ma et al.

PloS one, 7(6), e38734-e38734 (2012-06-23)

Pregnane X receptor (PXR) is known to function as a xenobiotic sensor to regulate xenobiotic metabolism through selective transcription of genes responsible for maintaining physiological homeostasis. Here we report that the activation of PXR by pregnenolone 16α-carbonitrile (PCN) in AKR/J

Nuclear receptor PXR, transcriptional circuits and metabolic relevance

Ihunnah CA, et al.

Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1812(8), 956-963 (2011)

查看所有相关文献

全球贸易项目编号

货号	GTIN
P0543-250MG	04061832851136
P0543-50MG	04061832851143
P0543-100MG	04061834304319

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持