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Merck
CN

P0622

Sigma-Aldrich

PET-cGMP

≥98% (HPLC), solid

别名:

β-Phenyl-1,N2-ethenoguanosine 3′,5′-monophosphate sodium salt

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关于此项目

经验公式（希尔记法）:
C18H15N5O7PNa
CAS Number:
78080-27-0
分子量:
467.30
MDL编号:
MFCD04118064
UNSPSC代码:
12352200
PubChem化学物质编号:
24724570
NACRES:
NA.77

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方案

≥98% (HPLC)

表单

solid

包装

pkg of 10 μmol

颜色

white

溶解性

H2O: ~10 mmol

运输

dry ice

储存温度

−70°C

SMILES字符串

[Na+].O[C@@H]1[C@@H]2OP([O-])(=O)OC[C@H]2O[C@H]1n3cnc4C(=O)N5C=C(NC5=Nc34)c6ccccc6

InChI

1S/C18H16N5O7P.Na/c24-13-14-11(7-28-31(26,27)30-14)29-17(13)23-8-19-12-15(23)21-18-20-10(6-22(18)16(12)25)9-4-2-1-3-5-9;/h1-6,8,11,13-14,17,24H,7H2,(H,20,21)(H,26,27);/q;+1/p-1/t11-,13-,14-,17-;/m1./s1

InChI key

IGIOCJJIGJLGKR-TZNCIMHNSA-M

生化/生理作用

cGMP-dependent protein kinase (PKG I and PKG II) activator. Potent membrane permeant activator of both isozymes I α and I β of cGMP-dependent protein kinase. Common stimulators such as 8-Br-cGMP or 8-pCPT-cGMP mainly activate kinase subtype Iα.

特点和优势

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
064K4730

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James C Campbell et al.
ACS chemical biology, 12(9), 2388-2398 (2017-08-10)
Cyclic GMP analogs, 8-Br, 8-pCPT, and PET-cGMP, have been widely used for characterizing cellular functions of cGMP-dependent protein kinase (PKG) I and II isotypes. However, interpreting results obtained using these analogs has been difficult due to their low isotype specificity.
Stephanie D Nofal et al.
mBio, 12(1) (2021-01-28)
Guanylyl cyclases (GCs) synthesize cyclic GMP (cGMP) and, together with cyclic nucleotide phosphodiesterases, are responsible for regulating levels of this intracellular messenger which mediates myriad functions across eukaryotes. In malaria parasites (Plasmodium spp), as well as their apicomplexan and ciliate
Matthew Tcheng et al.
Blood, 137(25), 3518-3532 (2021-03-16)
Acute myeloid leukemia (AML) cells have an atypical metabolic phenotype characterized by increased mitochondrial mass, as well as a greater reliance on oxidative phosphorylation and fatty acid oxidation (FAO) for survival. To exploit this altered metabolism, we assessed publicly available

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