生物来源
mouse
偶联物
unconjugated
抗体形式
ascites fluid
克隆
DCS-50, monoclonal
分子量
antigen 16 kDa
包含
15 mM sodium azide
种属反应性
human
技术
immunocytochemistry: suitable
immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:1,000 using a cultured human tumor cell line extract
同位素/亚型
IgG1
运输
dry ice
储存温度
−20°C
基因信息
human ... CDKN2A(1029)
免疫原
recombinant human p16 protein.
生化/生理作用
The antibody reacts specifically with the C-terminal (last 12 amino acids) of human p16 molecule (also known as p16INK4, p16INK4a, p16MTS1, inhibitor of CDK4). An additional application for this antibody is microinjection into cells.
法规信息
新产品
此项目有
J Lukas et al.
Cancer research, 55(21), 4818-4823 (1995-11-01)
The p16INK4/CDKN2, D-type cyclins, their partner cyclin-dependent kinases, and retinoblastoma protein constitute a G1 regulatory pathway commonly targeted in oncogenesis. We show that, unexpectedly, abnormalities of p16INK4/CDKN2 occur concomitantly in two-thirds of cancer cell lines harboring aberrations of cyclin D1.
J Lukas et al.
Nature, 375(6531), 503-506 (1995-06-08)
D-type cyclins, in association with the cyclin-dependent kinases Cdk4 or Cdk6, promote progression through the G1 phase of the cell cycle by phosphorylating the retinoblastoma protein (RB). The activities of Cdk4 and Cdk6 are constrained by inhibitors such as p16
A L Reed et al.
Cancer research, 56(16), 3630-3633 (1996-08-15)
The tumor suppressor gene p16 (CDKN2/MTS-1/INK4A) can be inactivated by multiple genetic mechanisms. We analyzed 29 invasive primary head and neck squamous cell carcinomas (HNSCC) for p16 inactivation with immunohistochemistry utilizing a new monoclonal antibody (mAb), DCS-50. p16 staining of
L Aagaard et al.
International journal of cancer, 61(1), 115-120 (1995-03-29)
The p16Ink4/MTS1/CDKN2 is a cell-cycle regulatory inhibitor of cyclin-dependent kinase 4 (cdk4), and a candidate tumour suppressor whose gene on chromosome band 9p21 is frequently deleted or mutated in diverse types of cancer. Cdk4 in association with its D-type cyclin
Ji-Seon Lee et al.
Stem cells (Dayton, Ohio), 27(8), 1963-1975 (2009-06-23)
Human mesenchymal stem cells (hMSCs) have been widely studied as a source of primary adult stem cells for cell therapy because of their multidifferentiation potential; however, the growth arrest (also known as "premature senescence") often found in hMSCs cultured in
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