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Merck
CN

P1038

Sigma-Aldrich

聚胞苷酸 钾盐

random copolymer

别名:

Poly (C,I)

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化学文摘社编号:
26301-44-0
MDL编号:
MFCD00167396
UNSPSC代码:
41106305
NACRES:
NA.51

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质量水平

200

表单

powder

储存温度

−20°C

应用

聚（胞苷肌苷）酸钾盐已用于：
  • 进行预处理，用于研究 Con A 诱发的小鼠肝炎
  • 血淋巴血浆 RNA 提取，用于 qPCR 检测分析
  • 诱导肝脏炎症变化
  • 作为刺激虹鳟鱼生殖腺 RTG-2 细胞的基本必需培养基的成分

生化/生理作用

聚（胞苷-肌苷）聚（C，I）是肌苷和胞苷碱的无规共聚物，可用于与其他无规共聚物（例如，Poly（C，A），Poly（C，U）和 Poly （C，G）进行比较理化分析。
聚（胞苷-肌苷）酸，聚 I：C 模仿病毒 RNA 诱导免疫反应。施加 poly I：C 可促进天然杀伤细胞和巨噬细胞的细胞毒性功能。但是，poly I：C 可能会触发抗线粒体抗体（AMA）的产生，并能促进原发性胆汁性肝硬化（PBC）的发病。Poly I：C 可能在 Con A 诱导的 T 细胞依赖性肝损伤中起保肝作用。

其他说明

无规共聚物

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000141154
063M4020V
086M4060V
12120609
093M4020V

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What can I use to solubilize Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038?

    The product is soluble in water at 10 mg/mL.

  4. How large/long a polymer is Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038?

    The average length of this polynucleotide has not been determined.

  5. Is Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038, single or double stranded?

    Product No. P1038 is a single-stranded random co-polymer.

  6. Will Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038, work to induce interferon production?

    P1038 is a single stranded RNA. For cell activation, synthetic double-stranded RNA is widely used as the ligand of Toll-like receptor 3 (TLR3) in place of what is supposed to be the natural ligand (viral dsRNA). This would be Product No. P9582, a double stranded RNA homopolymer, i.e. Poly(I): Poly(C). This product is widely used by other satisfied customers for cell activation.

  7. Is Poly(cytidylic-inosinic) acid potassium salt (Poly (C:I)), Product P1038, product sterile?

    Product No. P1038 is not sterile. The product is produced in non-sterile conditions and the level of endotoxin content is not determined.

  8. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  9. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I: C) and murine autoimmune cholangitis
Wang J, et al.
Journal of Hepatology, 44(3), 446-454 (2006)
G F Joyce et al.
Journal of molecular biology, 188(3), 433-441 (1986-04-05)
Poly(C, G) random copolymer templates direct the oligomerization of 2-Me-ImpG and 2-MeImpC, resulting in the production of a variety of oligo(G, C)s. The efficiency of monomer incorporation into newly synthesized oligomers is greater for 2-MeImpG than for 2-MeImpC, and decreases
Persistence of double-stranded RNA in insect hemolymph as a potential determiner of RNA interference success: evidence from Manduca sexta and Blattella germanica
Garbutt JS, et al.
Journal of Insect Physiology, 59(2), 171-178 (2013)
G F Joyce et al.
Journal of molecular biology, 176(2), 279-306 (1984-06-25)
Poly(C, U) random copolymer templates direct the oligomerization of 2-MeImpG and 2-MeImpA, resulting in the production of a variety of oligo/(G,A)s. The efficiency of monomer incorporation into newly synthesized oligomers is greater for 2-MeImpG than for 2-MeImpA, and decreases for
G F Joyce et al.
Journal of molecular biology, 202(3), 677-681 (1988-08-05)
Poly(C,A) random copolymer templates direct the oligomerization of 2-MeImpG (2-MeImpX is the 5'-phospho-2-methylimidazolide of the nucleoside X) and 2-MeImpU, resulting in the production of a variety of oligo (G,U)s. This reaction is less efficient than comparable reactions involving poly(C,U) or
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