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Merck
CN

P1038

聚胞苷酸 钾盐

random copolymer

别名:

Poly (C,I)

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关于此项目

化学文摘社编号:
UNSPSC Code:
41106305
NACRES:
NA.51
MDL number:
Form:
powder
Storage temp.:
−20°C
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Quality Level

form

powder

storage temp.

−20°C

Application

聚(胞苷肌苷)酸钾盐已用于:
  • 进行预处理,用于研究 Con A 诱发的小鼠肝炎
  • 血淋巴血浆 RNA 提取,用于 qPCR 检测分析
  • 诱导肝脏炎症变化
  • 作为刺激虹鳟鱼生殖腺 RTG-2 细胞的基本必需培养基的成分

Biochem/physiol Actions

聚(胞苷-肌苷)酸,聚 I:C 模仿病毒 RNA 诱导免疫反应。施加 poly I:C 可促进天然杀伤细胞和巨噬细胞的细胞毒性功能。但是,poly I:C 可能会触发抗线粒体抗体(AMA)的产生,并能促进原发性胆汁性肝硬化(PBC)的发病。Poly I:C 可能在 Con A 诱导的 T 细胞依赖性肝损伤中起保肝作用。
聚(胞苷-肌苷)聚(C,I)是肌苷和胞苷碱的无规共聚物,可用于与其他无规共聚物(例如,Poly(C,A),Poly(C,U)和 Poly (C,G)进行比较理化分析。

Other Notes

无规共聚物

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Persistence of double-stranded RNA in insect hemolymph as a potential determiner of RNA interference success: evidence from Manduca sexta and Blattella germanica
Garbutt JS, et al.
Journal of Insect Physiology, 59(2), 171-178 (2013)
G F Joyce et al.
Journal of molecular biology, 188(3), 433-441 (1986-04-05)
Poly(C, G) random copolymer templates direct the oligomerization of 2-Me-ImpG and 2-MeImpC, resulting in the production of a variety of oligo(G, C)s. The efficiency of monomer incorporation into newly synthesized oligomers is greater for 2-MeImpG than for 2-MeImpC, and decreases
G F Joyce et al.
Journal of molecular biology, 176(2), 279-306 (1984-06-25)
Poly(C, U) random copolymer templates direct the oligomerization of 2-MeImpG and 2-MeImpA, resulting in the production of a variety of oligo/(G,A)s. The efficiency of monomer incorporation into newly synthesized oligomers is greater for 2-MeImpG than for 2-MeImpA, and decreases for
The multi-hit hypothesis of primary biliary cirrhosis: polyinosinic-polycytidylic acid (poly I: C) and murine autoimmune cholangitis
Wang J, et al.
Journal of Hepatology, 44(3), 446-454 (2006)
G F Joyce et al.
Journal of molecular biology, 202(3), 677-681 (1988-08-05)
Poly(C,A) random copolymer templates direct the oligomerization of 2-MeImpG (2-MeImpX is the 5'-phospho-2-methylimidazolide of the nucleoside X) and 2-MeImpU, resulting in the production of a variety of oligo (G,U)s. This reaction is less efficient than comparable reactions involving poly(C,U) or

全球贸易项目编号

货号GTIN
P1038-10MG04061834353881
P1038-5MG04061834353898

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